Potential biomarkers for diagnosing neonatal sepsis

Sharma, Ankita; Thakur, Anup; Bhardwaj, Chitra; Kler, Neelam; Garg, Pankaj; Singh, Mahender; Choudhury, Sangeeta

doi:10.1016/j.cmrp.2019.12.004

Cited by 12 publications

(20 citation statements)

References 46 publications

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“…Interleukin–8 (IL–8) presents a rapid increase (in 1 to 3 h from stimulation), being an early phase marker in the detection of EOS, but has the disadvantage of a short half-life of only 4 h [ 18 , 27 , 33 , 34 , 57 ]. This cytokine has a moderate accuracy, with a sensitivity of 80–91% and a specificity of 75–100% [ 27 , 28 , 33 , 34 , 57 ]. For a cut-off value of >60 pg/mL, IL-8 presents a high sensitivity (95%) and PPV (97%) but a low specificity (10%) and NPV (10%) [ 57 ].…”

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

“…IL-8 does not only correlate with the severity of infection, but is also appears to be more efficient in diagnosing EOS prior to other markers (IL-6, IL-10) [ 28 , 30 , 32 , 34 , 57 ]. However, Sharma et al concluded that IL-8 alone is not useful in the diagnosis and prognosis of sepsis, probably because its concentration rises also in necrotizing enterocolitis (NEC), surgery, trauma and meconium aspiration syndrome [ 10 , 33 ]. If associated with CRP, the sensitivity and specificity of IL-8 increase [ 18 , 33 , 57 ].…”

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

“…However, Sharma et al concluded that IL-8 alone is not useful in the diagnosis and prognosis of sepsis, probably because its concentration rises also in necrotizing enterocolitis (NEC), surgery, trauma and meconium aspiration syndrome [ 10 , 33 ]. If associated with CRP, the sensitivity and specificity of IL-8 increase [ 18 , 33 , 57 ].…”

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

“…Even if IL–10 is not frequently studied as it is less expressed in neonates, an increased value is very suggestive for a severe infection, usually associated with multi organ damage [ 30 , 33 , 34 ]. It can predict the prognosis and survival of a neonate affected by sepsis [ 33 ].…”

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

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Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

et al. 2020

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Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up to 9.8% live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages. This comprehensive review article is based on the role of biomarkers currently in use or in the research phase from a basic, translational, and clinical viewpoint that helps us to improve the quality of neonatal early-onset sepsis diagnosis and management.

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Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

Section: Biomarkers Commonly Used or Under Consideration For Eos Dmentioning

confidence: 99%

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Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

et al. 2020

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“…Neutrophil CD64 (nCD64) is one of the most researchable sepsis biomarkers; it shows a valuable role in both diagnosing and monitoring infections in both early-onset and late-onset sepsis in either term or preterm newborns [ 4 , 6 , 9 – 13 ]. Further studies postulated a valuable prognostic role for nCD64 and diagnostic efficacy to discriminate between infectious and noninfectious systemic inflammatory response syndrome (SIRS) in ICU settings [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis

Hashem

Halim

Masry

et al. 2020

International Journal of Microbiology

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Background. Neonatal septicemia is a critical medical situation; current conventional laboratory methods still have many limitations and diagnostic obstacles. For this purpose, last decades have witnessed a challenge between the battery of sepsis biomarkers including many leukocyte surface antigens, not only for early diagnostic purposes but also for better follow-up and good management of sepsis patients. Aim. To evaluate the diagnostic, prognostic, and monitoring performance of both neutrophil CD64 (nCD64) and presepsin as sepsis biomarkers compared to each other and to the conventional laboratory sepsis parameters aiming to decide which is the best fitting for routine daily use in neonatal intensive care units (NICUs). Methods. 235 neonates were enrolled from three Egyptian neonatal ICUs, during the period from November 2015 till March 2018; they were classified into two main groups: the control group (n = 102) and the sepsis group (n = 133). Laboratory sepsis evaluation included highly sensitive CRP (hs-CRP), CBC, in addition to nCD64 (flow cytometry technique), and presepsin measurement (CLEIA technique combined with Magtration® technology); the diagnosis was confirmed thereafter by positive blood culture results (BacT/Alert system). Sixty-two of the enrolled sepsis neonates were subjected to follow-up assessment; they were reclassified according to their clinical improvement at the second time assessment into (group 1: sepsis group without improvement) (n = 20) and (group 2: improved sepsis group) (n = 42). Results. Significant increase in nCD64 and presepsin values was found in sepsis groups compared to the controls. At cutoff 41.6%, nCD64% could discriminate the presence of septicemia with sensitivity 94.7%, specificity 93.6 %, and AUC 0.925, while presepsin at cutoff 686 pg/ml achieves sensitivity 82.7%, specificity 95.5%, and AUC 0.887, respectively. Significant increase in nCD64 ( P < 0.001 ) and hs-CRP ( P = 0.018 ) values was observed in severe sepsis/septic shock patients compared to nonsevere sepsis patients. Delta change percentage (dC%) between initial and follow-up evaluations for both improved and nonimproved sepsis patients was dC Z value −5.904 for nCD64% followed by dC Z value −4.494 for presepsin. Conclusion. nCD64 and presepsin are valuable early diagnostic and monitoring sepsis biomarkers; the highest sensitivity could be achieved by a univariant sepsis marker in this study was recorded by the nCD64% biomarker, while the highest specificity was documented by presepsin. Combined measurement of both achieves the highest diagnostic performance in sepsis neonates. Either of CD64 or presepsin combined with hs-CRP associated with better performance than any of them alone. nCD64 carries an additional promising role in reflecting sepsis prognosis.

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Functionalization of hybrid surface microparticles for in vitro cellular antigen classification

et al. 2020

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Potential biomarkers for diagnosing neonatal sepsis

Cited by 12 publications

References 46 publications

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis

The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis

Functionalization of hybrid surface microparticles for in vitro cellular antigen classification

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