Potential biomarkers in hypoglycemic brain injury

Zhao, Suisheng; Liu, Zi-Hao; Ma, Longda; Yin, Min; Zhou, Yunjiao

doi:10.1007/s12024-023-00681-8

Cited by 3 publications

(1 citation statement)

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“…In recent years, several works have investigated the role of the proteome in the development of various pathologies, especially in cardiology. In the face of numerous clinical studies, the study of the proteome is progressively advancing in the forensic setting [ 25 ]. Despite its incredible potential, to date, the role of proteomics in diagnosing the etiopathogenetic mechanisms underlying SCD remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Sacco,

Gualtieri,

Calanna

et al. 2023

IJMS

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Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic purposes, as well as for judicial and preventive purposes for family members. Despite the completion of all routine post-mortem investigations, it is often complicated for the forensic pathologist to define the triggering cause of these events. The study of the proteome is proving to be extremely promising in the field of human cardiovascular disease. This paper aims to offer a literature review on the study of the proteome in post-mortem cadaveric biological samples obtained from SCD cases. The aim of this work is to outline the state of the art of the scientific advances that protein analysis can offer in the diagnosis of SCD and the limits that various studies have traced up to now. In conclusion, the work defines the future perspectives of this field in SCD, suggesting strategies to overcome the reported limits and improve the diagnostics of these events.

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Section: Introductionmentioning

confidence: 99%