Potential causal prophylactic antimalarial agents. Synthesis of quinoxaline, benzimidazole, and alkoxybenzene derivatives containing a novoldiamine moiety

Abstract

Several quinoxaline, benzimidazole, and alkoxybenzene derivatives containing the novoldiamine function, either as a side chain or incorporated as a ring constituent, were synthesized as potential causal prophylactic antimalarial agents. 1‐(5‐Dimethylamino‐2‐pentyl)‐5‐methoxy‐benzimidazole (2a) was shown to have the desired prophylactic activity in the preliminary sporozoitc‐indueed Plasmodium gallinaceum test.

U.V Spectroscopic study of Benzylidine p-toluenesulphonomide Schiff- bases in absolute methanol – Direct determination of trace amounts

“…Schiff Bases are a biologically important compounds due to their antitumor and carcinostatic activities [1], the biological activity of Schiff bases has application which is attributed to the formation of stable complexes with transition metals presents in the living cell [2], Schiff bases known to exhibit a wide variety of pharmacological properties such as antiflammatory [3] and antimalarial [4]. The medical field that Schiff Bases used are selective in the metabolic synthesis of amino acids since they act as a thyroid human antigen [5].…”