Background: The timely availability of safe and quality blood is a lifesaving decisive factor. Maintaining a stable and adequate blood supply has become a huge challenge amidst COVID 19 pandemic, especially in developing countries like India. Impact of this pandemic on blood transfusion services and potential challenges faced are discussed in the present study which helps planning acute blood shortage even in future pandemics. Objective: 1. To know the impact of COVID-19 pandemic on Blood bank service; 2. To suggest strategy to tackle acute crisis of blood in future disasters. Materials and Methods: In the present study six month's data pertaining to blood bank following, COVID 19 outbreak in district was compared with that of pre-COVID19 state. Donor attendance register, blood issue register, blood stock-component register, Voluntary blood donation camps, reagents and consumables stock inventory records are analyzed statistically. Mitigative measures adopted are discussed for smooth functioning of Blood bank services. Results: During COVID-19 outbreak there was drastic reduction in total number of voluntary blood donors visiting blood bank, cancellation of Voluntary blood camps, decreased number of blood components and discard rate of blood components was increased. Disruption of inventory stock maintenance was also seen. Conclusion: COVID 19 pandemic had a negative impact on Blood transfusion services. A multi-centric approach with evidence based emergency preparedness plan helps to overcome acute crisis of blood supply and in future disasters.