Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia

Santos, Beatriz da Silva; Silva, Manoela Santos da; Pereira, Isadora Oliveira e; Lemos, Leandro Borges; Lemos, Gisele da Silveira

doi:10.33448/rsd-v10i4.14250

Cited by 4 publications

(8 citation statements)

References 19 publications

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“…Losartan, hydrochlorothiazide, and simvastatin were the medicines most used by the population that did not practice self-medication (Table 5). 1 Self-medication: yes = all interviewees reported using the drug for self-medication; partial = A portion of the interviewees, but not all, reported using the drug for self-medication. Medicines.…”

Section: Resultsmentioning

confidence: 99%

“…Medicines. 1 Self-medication: no = none of the interviewees reported using the drug for self-medication.…”

Section: Resultsmentioning

confidence: 99%

“…Medicines are considered one of the main resources for maintaining health as they positively help in improving the quality of life of the population [ 1 ]. The drug treatment must be used correctly to achieve effectiveness, safety, and success, as it can damage to the patient’s health when used improperly [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Self-Medication during the COVID-19 Pandemic in Brazil: Findings and Implications to Promote the Rational Use of Medicines

Bazoni,

Faria,

Cordeiro

et al. 2023

IJERPH

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Self-medication is identified by the consumption of medications without a prescription or guidance from a qualified prescribing professional. This study estimated the prevalence, profile, and associated factors with self-medication during the COVID-19 pandemic in Brazil. A cross-sectional study was conducted through a household survey in the Alegre city, from November to December 2021. Descriptive analysis was performed for the sociodemographic and clinical characteristics of the interviewees. Poisson regression with robust variance was used to identify the association of sociodemographic and clinical variables with self-medication. A total of 654 people were interviewed, of whom 69.4% were self-medicating. The younger age group (PR = 1.13; 95% CI = 1.01–1.26), female gender (PR = 1.19; 95% CI = 1.04–1.37), consumption of alcoholic beverages (PR = 1.13; 95% CI = 1.01–1.25), and problems with adherence to pharmacological treatment (PR = 1.15; 95% CI = 1.04–1.28) were associated with self-medication, while the occurrence of polypharmacy (PR = 0.80; 95% CI = 0.68–0.95) was a protective factor for self-medication. Self-medication was directly related to over-the-counter drugs, with analgesics dipyrone and paracetamol being the most commonly used. Self-medication consumption of prescription drugs, including those under special control, was identified to a lesser extent.

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Section: Resultsmentioning

confidence: 99%

“…Medicines. 1 Self-medication: no = none of the interviewees reported using the drug for self-medication.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Self-Medication during the COVID-19 Pandemic in Brazil: Findings and Implications to Promote the Rational Use of Medicines

Bazoni,

Faria,

Cordeiro

et al. 2023

IJERPH

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“…Além disso, analgésicos e antimicrobianos podem ser prescritos em concomitância aos anti-inflamatórios [31,[35][36][37], visto que são comumente utilizados para o tratamento de sintomas associados aos processos infecciosos [36]. No entanto, devido à possibilidade desses medicamentos causarem interações e provocarem reações adversas, esta situação é preocupante, uma vez que o uso desses fármacos de forma inadequada, com superdosagem ou por tempo prolongado, pode representar perigo à saúde dos usuários [37][38][39] como risco de toxicidade, ocasionar dependência e resistência microbiana, além de aumento dos custos com a saúde. Esse conjunto de fatores associados pode causar um comprometimento na terapia medicamentosa, resultando em um grave problema de saúde pública [36,37,40,41].…”

Section: Discussionunclassified

Medicamentos vencidos e/ou armazenados no domicílio de estudantes e o correto descarte: um estudo de caso

Rodrigues Tassara,

Pires,

Sousa

et al. 2022

Rev. Colomb. Cienc. Quím. Farm.

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Objetivos quantificar e qualificar por classes terapêuticas os medicamentos vencidose/ou armazenados no domicílio de estudantes dos cursos técnicos do eixo saúde doColégio Tecnológico Jerônimo Carlos do Prado, em Goiatuba, GO. Metodologia:a pesquisa foi realizada através de coleta de medicamentos em desuso obtidos dafarmácia domiciliar dos estudantes por entrega voluntária e anônima. Resultados:foram coletados 86 medicamentos, dos quais 77,9% estavam com a validade expirada.O número de medicamentos prescritos sem retenção de receita foi maior em relaçãoaos prescritos com retenção de receita e venda livre. A classe terapêutica mais comumfoi o anti-inflamatório não-esteroide, seguido dos analgésicos e os antimicrobianos.Alguns medicamentos apresentaram lascas e alteração de cor dos comprimidos e,no caso das soluções, foram encontradas crostas ao redor da tampa, evidenciandooxidação e alteração do produto. Conclusões: logo, mesmo entre estudantes daárea de saúde ocorre a prática do armazenamento de medicamentos e alguns emcondições inadequadas. A aquisição racional de medicamentos deve ser um temaimprescindível a ser trabalhado em todos os níveis de ensino e também nas palestras educativas oferecidas pelas Unidades Básicas de Saúde. A população precisa deeducação em saúde para apreender sobre as práticas corretas de armazenamento edescarte de medicamentos.

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“…In this context, studies that analyze the impact of polytherapy on bacterial resistance report that the use of a greater number of antibiotics is related to a greater risk of developing drug interactions (DI). Thus, it should be noted that a complication of great importance to global public health is the emergence of resistant bacteria, directly linked to the inappropriate use of antibiotics, with DI induced by polytherapy, one of the factors that corroborate the development of resistant strains, for interfering with the effectiveness of the drug [23]. In addition, one of its possible results for the patient's health is the potentiation of the adverse effects of a given drug, which increases the rate of treatment abandonment [23,24].…”

Section: Regardingmentioning

confidence: 99%

A Retrospective Cohort Analysis of the Treatment of Bacterial Pneumonia Pediatric Cases

Amaral

Leite

Bié

et al. 2023

JAMMR

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Aims: The present study aims to evaluate the use of antibiotics in the management of bacterial pneumonia in the pediatric sector of a teaching hospital. Study Design: A retrospective and descriptive cross-sectional study. Place and Duration of Study: The pediatrics sector of the Julio Bandeira University Hospital (HUJB), Brazil from September 2017 to December 2021. Methodology: A total of 734 medical records were analyzed, based on two groups: a) For those subjects who adhered to the protocol (AP) and b) for those who did not (DP), which were already recommended in the agreement described in the guidelines of hospital. The data were analyzed in a descriptive and exploratory way to evaluate the distribution and characterize the study population, so that the categorical variables were presented in the form of absolute (n) and relative (%) frequencies, while the continuous variables were evaluated through measures of central tendency and dispersion. As the data distribution did not adhere to normality, the differences between the proportions of categorical variables were evaluated by the Chi-square test (5% significance level), while the differences between the medians by the U-Mann-Whitney test. Results: The results found indicate greater effectiveness in the group that followed the institution's protocol (95.93%), as well as less use of antibiotics in therapy, making the majority use of monotherapy (74%), and adequacy to the duration of therapy (OR=1.49). In addition, there was an increase in the use of azithromycin during the Covid-19 pandemic. Conclusion: The group that adhered to the protocol stood out over the group that did not adhere to the protocol in terms of greater effectiveness. Of treatment, less use of antibiotics and adequate length of stay for the prescribed treatment. Furthermore, a growth in the use of azithromycin was observed during the years of the Covid-19 pandemic.

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Potential drug interactions and profile of antimicrobials prescribed for outpatient use in the interior of Bahia

Cited by 4 publications

References 19 publications

Self-Medication during the COVID-19 Pandemic in Brazil: Findings and Implications to Promote the Rational Use of Medicines

Self-Medication during the COVID-19 Pandemic in Brazil: Findings and Implications to Promote the Rational Use of Medicines

Medicamentos vencidos e/ou armazenados no domicílio de estudantes e o correto descarte: um estudo de caso

A Retrospective Cohort Analysis of the Treatment of Bacterial Pneumonia Pediatric Cases

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