Potential emerging chemical risks in the food chain associated with substances registered under REACH

Oltmanns, Jan; Licht, Oliver; Bohlen, Marie‐Léonie; Schwarz, Maik; Escher, Sylvia; Silano, Vittorio; MacLeod, Matthew; Noteborn, H.P.J.M.; Kass, George E.N.; Merten, Caroline

doi:10.1039/c9em00369j

Cited by 8 publications

(4 citation statements)

References 47 publications

(70 reference statements)

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“…While several molecular structures were possible, compound 19 may have been related to tert-butylphenol or may be a transformation product of 6,6′-di-tert-butyl-2,2′-methylenedip-cresol (DBMC; CAS 119-47-1; ECHA), 37 which is used in rubber as an antioxidant and stabilizer. 38 The loss of C 6 H 8 visible in the product ion spectrum of compound 19 could be attributed to a hexatriene linked by a heteroatom bond (Figure S8).…”

Section: Resultsmentioning

confidence: 99%

Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates

Klöckner

Seiwert

Wagner

et al. 2021

Environ. Sci. Technol.

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Tire and road wear particles (TRWPs) are one of the main sources of particulate traffic emissions, but measured data on TRWP contents in the environment are scarce. This study aims at identifying organic compounds suitable as quantitative markers for TRWPs by a tiered multistep selection process involving nontarget screening and subsequent identification by liquid-chromatography high-resolution mass spectrometry. Starting from several thousands of signals recorded in the extract of tire particles, the rigorous selection process considered source specificity, tendency of leaching, analytical sensitivity and precision, and stability during aging. It led to three transformation products of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) as the most suitable marker candidates: N-formyl-6-PPD, hydroxylated N-1,3dimethylbutyl-N-phenyl quinone diimine, and 6-PPD-quinone. A linear response in standard addition experiments with tire particles and the correlation with TRWP contents in a diverse set of environmental samples imply that these compounds are promising candidates as markers for the quantification of TRWPs. Organic markers for TRWP contents in the environment would allow TRWP quantification with the traditional tandem MS (LC−MS/MS) equipment of an organic trace analytical laboratory and, thus, allow easy generation of data on TRWP occurrence in sediments and soils and other environmental matrices.

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Section: Resultsmentioning

confidence: 99%

Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates

Klöckner

Seiwert

Wagner

et al. 2021

Environ. Sci. Technol.

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“…Once the presence of food safety hazards in the final food product is assessed using the criteria indicated above, its severity should be taken into account in order to estimate the potential effects on human health. The health effects of a chemical food safety hazard can be assessed by taking into account the four endpoints of toxicity as established by 55 : carcinogenicity (categories Carc.1 A, 1B, 2 according to IARC), mutagenicity (categories Muta.1 A, 1B, 2), reprotoxicity (categories Repr.1 A, 1B, 2), and repeated dose toxicity (category STOT RE 1 and 2). A classification in one of these endpoints is seen as indication of human health risks and is evaluated as high effect on human health 56 .…”

Section: Transfer To the Edible Parts Of The Plants Or Animalsmentioning

confidence: 99%

Framework for evaluation of food safety in the circular food system

van der Fels-Klerx,

van Asselt,

Berendsen

et al. 2024

npj Sci Food

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In order to minimise food waste, side streams from feed and food production are increasingly being (re-) used in food supply chains. Such reuse contributes to the desire to implement circularity in food and agricultural systems. However, the reuse of side products in circular food systems may impact food safety, for instance, contaminant residues present at low levels in biomass may accumulate when reusing streams. In order to assess potential food safety issues related to circular food systems, a framework has been developed in this study. Based on this framework, appropriate actions can be taken to prevent from human health risks. The framework consists of three steps: 1. Describing the changes in the food supply chain as a result of the circularity transition; 2. Identifying potential food safety hazards related to the change; and 3. Prioritising food safety hazards related to the circularity transition. For the prioritisation, both the presence of the hazards in final foods and the effects of the hazards on human health need to be assessed. Persistence of the hazard in the environment and potential transfer from the environment to the final food product are relevant elements to include. The framework was tested in three case studies, showing that it allows for a prioritisation between hazards. Based on the case study results, circularity not so much influences the health effects of the hazards, but rather their presence depending on the persistence and transfer of food safety hazards in a circular system.

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“…unknown emerging chemical issues or risks; and (b) a set of known priority chemicals with emerging risk potential (Oltmanns et al, 2019;Oltmanns et al, 2020).…”

Section: Data Intelligence Tool For Emerging Chemical Risks -Jrc Tool...mentioning

confidence: 99%

EFSA's activities on emerging risks in 2020

Bottex¹,

Gkrintzali²,

Matas³

et al. 2023

EFS3

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The main objectives of EFSA's activities on emerging risks are: (i) to carry out activities to identify emerging risks; (ii) to develop and improve emerging risk identification (ERI) methodologies and approaches; and (iii) communicate the issues and risks identified. The outcome of these activities also allows EFSA to prepare for future risk assessment challenges. The current technical report summarises the activities of all groups involved in the ERI procedure, the issues identified in the course of 2020, a description of the methodologies that have been considered, and collaborative activities. EFSA networks of knowledge contributing to the ERI activity include the Emerging Risks Exchange Network (EREN), the Stakeholder Discussion Group on Emerging Risks, EFSA's scientific units, scientific panels and the Scientific Committee. In total, 13 potential emerging issues were discussed in 2020. Six were concluded to be emerging issues. The potential issues were organised according to the hazard or driver identified. In addition, in 2020, EREN network members presented and discussed a total of 35 signals/potential emerging issues that had been identified by their own horizon‐scanning activities. Member State representatives shared their work on signal identification with the objective of collecting additional information that could be used for better characterisation. It is crucial to introduce more dynamic and interactive approaches to gather and disseminate knowledge, while also taking into consideration the potential risks that may arise in new areas.

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Potential emerging chemical risks in the food chain associated with substances registered under REACH

Abstract: A screening procedure for the identification of potential emerging chemical risks in the food and feed chain developed in a previous EFSA-sponsored study was applied to 15021 substances registered under the REACH regulation at the time of evaluation.

Cited by 8 publications

References 47 publications

Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates

Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates

Framework for evaluation of food safety in the circular food system

EFSA's activities on emerging risks in 2020

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