Potential for Biomedical Applications of Galactomannans and Xyloglucans from Seeds: An Overview

Abstract

Galactomannans and xyloglucans can be isolated from seeds with relatively high purity and yield; they are water soluble, non-toxic, and biocompatible. These polymers have broad spectra of potential use in medicine, from drug delivery systems to biological response modifiers. The biological activity of polysaccharides is intrinsically linked to their structural aspects. In general the chemical modification of galactomannans and xyloglucans, e.g., sulfation and complexation with oxovanadium, potentiate effects such as cytotoxicity against tumor cells, leishmanicidal activity, and activation of macrophages to release proinflammatory mediators. The wide range of seeds and structural variety favor the isolation of galactomannans and xyloglucans. This allows derivatives to be obtained with targeted properties and activity enabling their use in new applications in the biomedical area.

Fenugreek (Trigonella foenum graecum) gum: A functional ingredient with promising properties and applications in food and pharmaceuticals—A review

“…The polymer has high molecular weight, is rich in hydroxyl groups, and easily forms hydrogen bonds with water to form a viscous solution. The galactomannans are nontoxic (Noleto & Petkowicz, 2016), highly‐soluble, film‐forming (Kurt & Kahyaoglu, 2014), and controlled‐release (Burke et al, 2005) polymers and can also be used as an alternative material for synthetic polymers (Salarbashi et al, 2019). Various researches have focused on the characterizations of fenugreek gum and evaluation of its potential applications in foods, food products, pharma, and textile and different industrial uses.…”