Potential for Osseous Regeneration of Platelet-Rich Fibrin—A Comparative Study in Mandibular Third Molar Impaction Sockets

Varghese, Mathew P.; Manuel, Suvy; Kumar, Lakshya

doi:10.1016/j.joms.2017.01.035

Cited by 48 publications

(36 citation statements)

References 15 publications

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“…[ 6 ] This retrospective review demonstrated that preventative treatment of localized osteitis could be accomplished using a low cost, autogenous, soluble, biologic material, PRF, and that PRF enhanced third molar socket healing/clot retention and greatly decreased the clinical time required for postoperative management of localized osteitis. [ 6 ] Since then, many studies have evaluated the use of LPRF and PRF to facilitate implant placement and periapical surgeries,[ 37 38 ] revascularization procedures,[ 39 ] perforation repair, and also bone regeneration in oral and maxillofacial region. [ 38 ]…”

Section: Discussionmentioning

confidence: 99%

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The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

et al. 2018

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Objective:The aim of this study was to evaluate the effect of LPRF, placed in extraction sockets, on orthodontic tooth movement (OTM).Materials and Methods:Thirty extraction sockets from eight patients (five males, three females, with a mean age of 17.37 years; range 12–25 years) requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. In one randomly selected quadrant of each jaw, the extraction socket was preserved as the experimental group by immediate placement of LPRF in the extraction socket. The other quadrant served as the control group for secondary healing. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. A piece of 0.016 × 0.022-inch stainless steel wire was used as the main arch wire. The amount of OTM was measured on the study casts at eight time points with 2-week intervals for 3 months. Analysis of random effect model was performed for the purpose of comparison between the experimental and control groups.Results:According to the random effect model, a statistically significant difference was found between the experimental and control group in rate of OTM (P = 0.006).Conclusion:According to the results, application of LPRF, as an interdisciplinary approach combining orthodontics and surgery, may accelerate OTM, particularly in extraction cases.

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Section: Discussionmentioning

confidence: 99%

“…[ 6 ] Since then, many studies have evaluated the use of LPRF and PRF to facilitate implant placement and periapical surgeries,[ 37 38 ] revascularization procedures,[ 39 ] perforation repair, and also bone regeneration in oral and maxillofacial region. [ 38 ]…”

Section: Discussionmentioning

confidence: 99%

The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

et al. 2018

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“…Resorptive remodeling of the alveolar ridge commonly occurs following tooth extraction. This process may be beneficial in fixed orthodontic treatment of patients with severe crowding [17][18][19]. Adequate volume of alveolar bone is a prerequisite for successful orthodontic tooth movement during space closure.…”

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confidence: 99%

The Effect of a Plasma With Platelet-rich Fibrin in Bone Regeneration and on Rate of Orthodontic Tooth Movement in Adolescents

Nemtoi¹,

Sirghe²,

Nemtoi³

et al. 2019

Rev. Chim.

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The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF), placed in extraction sockets, on bone regeneration and orthodontic tooth movement in adolescents. Fourty extraction sockets from twenty patients requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. The bone regeneration and the amount of orthodontic tooth movement was evaluated.

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“…Most of the available RCTs and controlled studies comparing L‐PRF to unassisted socket healing reported a benefit when L‐PRF was applied in terms of early (up to 8 weeks) (Alzahrani, Murriky & Shafik, ; Hauser, Gaydarov, Badoud, Vazquez & Bernard, ) and late (up to 16 weeks) (Temmerman, Vandessel, Castro, Jacobs & Teughels, ; Varghese, Manuel & Kumar, ) radiographic bone fill and horizontal/vertical alveolar preservation (Appendix S3), faster soft tissue healing, reduced pain and reduced post‐extraction sequelae (Marenzi, Riccitiello, Tia, Lauro & Sammartino, ; Ozgul, Senses, Er, Tekin & Tuz, ; Singh, Kohli & Gupta, ; Suttapreyasri & Leepong, ; Temmerman et al., ; Varghese et al., ; Zhang, Ruan, Shen, Tan & Huang, ). Moreover, the use of L‐PRF in third molars’ extractions has been associated with an improvement in second molars’ periodontal parameters (Kumar, Prasad, Ramanujam, Dexith & Chauhan, ) and a nearly tenfold decrease in the incidence of osteomyelitis compared to natural healing (Hoaglin & Lines, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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Potential for Osseous Regeneration of Platelet-Rich Fibrin—A Comparative Study in Mandibular Third Molar Impaction Sockets

Cited by 48 publications

References 15 publications

The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

The Effect of a Plasma With Platelet-rich Fibrin in Bone Regeneration and on Rate of Orthodontic Tooth Movement in Adolescents

The use of bioactive factors to enhance bone regeneration: A narrative review

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