Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from Passiflora ligularis (Granadilla)

Abstract

The consumption of fruits or by-products from plants of the Passifloraceae family has been associated with multiple health and nutritional benefits, due to their phenolic compound content. Likewise, the effects of polyphenols from Camellia sinensis (green tea) have been explored and are considered a reference for different biological actions of these bioactive substances. This study compared the hypoglycemic and antilipemic activity of polyphenol-rich extracts of Passiflora ligularis Juss (passion fruit) and Camellia sinensis (green tea) given to a group of Wistar rats induced to be overweight. The individuals were subjected to three doses of supplementation of both sources of polyphenols in the drinking water. An additional group without polyphenol supplementation served as a control group. Water consumption, weight gain, glycemia, cholesterol, serum triglycerides and percentage of fecal ethereal extracts were analyzed. Although Passiflora ligularis Juss had five times less polyphenol content than Camellia sinensis, rats fed doses of 2.5 and 3.0 g/L Passiflora ligularis Juss showed reduced glycemia by 16%, suggesting an antiglycemic activity similar to that of Camellia sinensis. On the other hand, higher doses of polyphenols from Passiflora ligularis Juss and Camellia sinensis significantly reduced triglyceride levels (p = 0.05) by more than 17% compared to the unsupplemented control group. The polyphenol-rich extracts produced effective inhibitory activity of lipemic metabolites with a reduction in the percentage of fecal lipids (p < 0.05), with no side effects on liver tissue. The 3.0 g/L dose produced the best result on signs of metabolic syndrome associated with excess weight. Polyphenols extracted from fresh Colombian passion fruit showed the potential to decrease metabolic syndrome risk factors in a murine model.

Antidiabetic Effect of Passiflora ligularis Leaves in High Fat-Diet/Streptozotocin-Induced Diabetic Mice

“…Similar behavior was also reported for different extracts of P. edulis in diabetic rats, attributed to glycosyl flavonoids [ 51 , 52 ]. Improvements in the lipid profile have been demonstrated by P. ligularis in obese rats and is correlated with the decrease in hepatic steatosis [ 53 ]. The results of the present study are according to previous studies which demonstrated the antilipidemic activity of isoquercetin in a dependent dosage which attenuated triglycerides and cholesterol levels in diabetic mice [ 38 ].…”

Model Matematis Massa Buah Markisa Manis (Passiflora ligularis Juss) Berbasis Beberapa Sifat Fisik

“…doi https://doi.org/10.21776/ub.jkptb.2023.011.03.09 1. Pendahuluan Passiflora merupakan sebuah genus tanaman rambat atau disebut juga spesies tanaman semak yang memiliki lebih dari 500 spesies di seluruh dunia [1], [2]. Berbagai penelitian melaporkan bahwa bagian tanaman Passiflora memiliki sifat anti inflamasi, antioksidan, dan anti tumor.…”