Potential Lives Saved Through Widespread Global Availability of GLP-1 Receptor Agonists: A Modeling Study

Abstract

This model attempts to quantify the potential impact of GLP-1 receptor agonists (GLP-1) in reducing global mortality linked to obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). Using global population data, T2DM and obesity prevalence, cardiovascular risk, and mortality reduction from GLP-1s, we estimate that ~943,000 lives could be saved annually with widespread global access to GLP-1 receptor agonists for individuals with obesity and/or T2DM and CVD.