Potential low toxic alternative for Na-Cl cotransporter inhibition: A diuretic effect and mechanism study of Pyrrosia petiolosa

He, Hanjiao; Sui, Yi; Xiang, Yu; Luo, Guoyong; Xue, Juan; Yang, Wenjie; Yi, Long

doi:10.1016/j.pharma.2023.07.002

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Diuretics are important for treating many diseases, including hypertension, kidney disorders, and acute heart failure [ 26 , 27 , 28 , 29 ]. However, because chemically synthesized diuretics used in clinical practice have potential side effects [ 30 , 31 , 32 ], there is a need for natural diuretics. In traditional Chinese medicine, rice bean has been used as a natural diuretic.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Gong,

Zhang,

Yao

et al. 2024

Nutrients

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Rice bean [Vigna umbellata (Thunb.) Ohwi and Ohashi], an annual legume in the genus Vigna, is a promising crop suitable for cultivation in a changing climate to ensure food security. It is also a medicinal plant widely used in traditional Chinese medicine; however, little is known about the medicinal compounds in rice bean. In this study, we assessed the diuretic effect of rice bean extracts on mice as well as its relationship with the contents of eight secondary metabolites in seeds. Mice gavaged with rice bean extracts from yellow and black seeds had higher urinary output (5.44–5.47 g) and water intake (5.8–6.3 g) values than mice gavaged with rice bean extracts from red seeds. Correlation analyses revealed significant negative correlations between urine output and gallic acid (R = −0.70) and genistein (R = −0.75) concentrations, suggesting that these two polyphenols negatively regulate diuresis. There were no obvious relationships between mice diuresis-related indices (urine output, water intake, and weight loss) and rutin or catechin contents, although the concentrations of both of these polyphenols in rice bean seeds were higher than the concentrations of the other six secondary metabolites. Our study findings may be useful for future research on the diuretic effects of rice bean, but they should be confirmed on the basis of systematic medical trials.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Gong,

Zhang,

Yao

et al. 2024

Nutrients

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“…Nevertheless, the utilization of these pharmacological agents is coupled with potential side effects or adverse consequences. Improper or excessive use of diuretics can lead to electrolyte and fluid loss, triggering compensatory mechanisms such as the renin–angiotensin system (RAS), which increases renal sodium retention throughout the nephron [ 4 , 5 ]. Therefore, there is an urgent need to develop alternative drugs that are more effective and have fewer side effects.…”

Section: Introductionmentioning

confidence: 99%

Constituents of Chimaphila japonica and Their Diuretic Activity

Yu,

Hu,

Liu

et al. 2024

Molecules

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Three new phenols (1–3), one new cyclohexanol (4), two known phenols (5–6), and six known flavonoids (7–12) were isolated from the n-butanol of the 75% ethanol extract of all plants of Chimaphila japonica Miq. Among them, compound 5 was named and described in its entirety for the first time, and compounds 9 and 10 were reported in C. japonica for the first time. The structures of all compounds were confirmed using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. Biological results show that compounds 4, 7, and 11 exhibited potent diuretic activity. The modes of interaction between the selected compounds and the target diuretic-related WNK1 kinase were investigated in a preliminary molecular docking study. These results provided insight into the chemodiversity and potential diuretic activities of metabolites in C. japonica.

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Research and utilization status of Lophatherum gracile: A medicinal and food homologous plant

Yao,

Zhang,

Zhao

et al. 2024

Chinese Herbal Medicines

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Potential low toxic alternative for Na-Cl cotransporter inhibition: A diuretic effect and mechanism study of Pyrrosia petiolosa

Cited by 4 publications

References 20 publications

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Assessment of the Diuretic Properties of Rice Bean Accessions Using a Mouse Model and Identification of Active Polyphenolic Compounds

Constituents of Chimaphila japonica and Their Diuretic Activity

Research and utilization status of Lophatherum gracile: A medicinal and food homologous plant

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