2010
DOI: 10.1111/j.1749-6632.2010.05599.x
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Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus

Abstract: Nitric oxide (NO) bioavailability is crucial for normal vascular endothelial function and health. Recent studies have demonstrated an endocrine role for NO equivalents that may be transported in the blood to peripheral tissue beds, where under hypoxic conditions they can liberate NO and cause vasodilation. Exercise training improves endothelial function but its effect on NO bioavailability in peripheral tissues during acute exercise stress in CVD is unclear. This paper will present evidence and discuss possibl… Show more

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Cited by 19 publications
(14 citation statements)
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“…These processes result in a lower NO release and thus a decreased vasodilation (Asano et al, 2012;Stabler, Katherine, Ham, Jelesoff, & Allen, 2010). Therefore, these factors could partially explain the impaired ability that individuals with T2D have to present PEH, especially when exercise is performed at lower intensities.…”
Section: S80mentioning
confidence: 99%
See 1 more Smart Citation
“…These processes result in a lower NO release and thus a decreased vasodilation (Asano et al, 2012;Stabler, Katherine, Ham, Jelesoff, & Allen, 2010). Therefore, these factors could partially explain the impaired ability that individuals with T2D have to present PEH, especially when exercise is performed at lower intensities.…”
Section: S80mentioning
confidence: 99%
“…This could be partially explained by the decreased activity of plasma kallikrein (Motta et al, 2010), as well as a lower NO release in this population (Asano et al, 2012;Stabler, Katherine, Ham, Jelesoff, & Allen, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Decreased nitric oxide synthesis is one of the symptoms of endothelium dysfunction, which further contributes to the deterioration of regulation of blood vessel wall tone [16]. It is believed that under such circumstances, the vascular endothelium may compensate to some extent by secreting other vasodilatory factors.…”
Section: Introductionmentioning
confidence: 99%
“…Evidences support that male infertility is associated with oxidative stress (Narasimhan et al ., ). Oxidative stress development in sperm pellets of cyproterone acetate‐treated rats may be due to high levels of uncoupler protein synthesis in testis or in epididymis (Stabler et al ., ) leads to increased reactive oxygen species (ROS) generation. In this study, it was supported by diminished activities of antioxidative enzymes, that is, catalase, peroxidase, SOD and glutathione‐ S ‐transferase, and higher levels of lipid peroxidative end products, i.e., CD and TBARS.…”
Section: Discussionmentioning
confidence: 99%