Potential nanocarriers for the delivery of drugs to the brain

Varghese, Nila Mary; Senthil, V.

doi:10.1016/b978-0-08-102985-5.00019-x

Cited by 2 publications

(1 citation statement)

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“…Polymers are materials that are widely investigated for different biomedical applications. Especially PLGA, as a material approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA), is often used in medical devices such as degradable sutures and screws for osteosynthesis and osteochondral fixation [19,36,37]. Nanoparticles fabricated with the use of PLGA, loaded with drugs or different active substances, are of great interest.…”

Section: Discussionmentioning

confidence: 99%

Porous Zirconia Scaffolds Functionalized with Calcium Phosphate Layers and PLGA Nanoparticles Loaded with Hydrophobic Gentamicin

Pudełko

Moskwik

Kwiecień

et al. 2023

IJMS

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Implant-related infections are a worldwide issue that is considered very challenging. Conventional therapies commonly end up failing; thus, new solutions are being investigated to overcome this problem. The in situ delivery of the drug at the implant site appears to be more sufficient compared to systemic antibiotic therapy. In this study, we manufactured porous zirconia scaffolds using the foam replication method. To improve their overall bioactivity, they were coated with a calcium phosphate (CaP) layer containing antibiotic-loaded degradable polymer nanoparticles (NPs) obtained by the double emulsion method to achieve the antibacterial effect additionally. Encapsulation efficiency (EE) and drug loading (DL) were superior and were equal to 99.9 ± 0.1% and 9.1 ± 0.1%, respectively. Scaffolds were analyzed with scanning electron microscopy, and their porosity was evaluated. The porosity of investigated samples was over 90% and resembled the microstructure of spongy bone. Furthermore, we investigated the cytocompatibility with osteoblast-like MG-63 cells and antimicrobial properties with Staphylococcus aureus. Scaffolds coated with a CaP layer were found non-toxic for MG-63 cells. Moreover, the presence of antibiotic-loaded nanoparticles had no significant influence on cell viability, and the obtained scaffolds inhibited bacteria growth. Provided processes of fabrication of highly porous zirconia scaffolds and surface functionalization allow minimizing the risk of implant-related infection.

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Section: Discussionmentioning

confidence: 99%