2019
DOI: 10.1097/fbp.0000000000000512
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Potential new therapies against a toxic relationship: neuroinflammation and Parkinson’s disease

Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder classically associated with motor symptoms, but several nonmotor disturbances appear decades before the clinical diagnosis of the disease. A variety of hypotheses exist to explain the onset of PD, and neuroinflammation is one of the most investigated processes. In fact, strong evidence suggests that PD begins with an inflammatory process; currently, however, no anti-inflammatory therapy is clinically employed to alleviate the typical motor and the prodro… Show more

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Cited by 10 publications
(9 citation statements)
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“…The etiology of PD is still unclear, and the accumulated evidences demonstrate that neuroin ammation plays an important role in the occurrence and development of PD. When neuroin ammation occurs, the immune cells, mainly microglia are over-activated to release proin ammatory mediators, resulting in the degeneration of peripheral neurons [24][25][26]. Therefore, inhibition of neuro-in ammation is also considered to be a target for the treatment of PD.…”
Section: Discussionmentioning
confidence: 99%
“…The etiology of PD is still unclear, and the accumulated evidences demonstrate that neuroin ammation plays an important role in the occurrence and development of PD. When neuroin ammation occurs, the immune cells, mainly microglia are over-activated to release proin ammatory mediators, resulting in the degeneration of peripheral neurons [24][25][26]. Therefore, inhibition of neuro-in ammation is also considered to be a target for the treatment of PD.…”
Section: Discussionmentioning
confidence: 99%
“…When neuroin ammation occurs, the immune cells, mainly microglia are over-activated to release proin ammatory mediators, resulting in the degeneration of peripheral neurons [24][25][26]. Therefore, inhibition of neuro-in ammation is also considered to be a target for the treatment of PD.…”
Section: Discussionmentioning
confidence: 99%
“…This supports cannabinoid drugs as potential therapeutic tools for CICI. Indeed, several studies have analyzed the neuroprotective actions of cannabinoid drugs in pathologies that occur with both, a neuroinflammatory response and cognitive impairments, but have different aetiologies, such as Parkinson’s disease (PD), Alzheimer’s disease (AD) and traumatic brain injury (TBI) (Schurman and Lichtman, 2017; Rodrigues et al , 2019; Uddin et al , 2020).…”
Section: Cannabinoids and Chemotherapy-induced Cognitive Impairmentmentioning
confidence: 99%