Potential of enzymatic process as an innovative technology to remove anticancer drugs in wastewater

Pereira, Cláudia Maria; Kelbert, Maikon; Daronch, Naionara Ariete; Michels, Camila; Oliveira, Débora de; Soares, Hugo Moreira

doi:10.1007/s00253-019-10229-y

Cited by 38 publications

(14 citation statements)

References 60 publications

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“…Cell-free enzymes in solution are poorly stable and their active sites can be inhibited. This increases the cost associated with this technology, since each enzymes can be used only once [7]. However, it is possible to increase the production, efficiency and stability of enzymes or mycelium by using immobilization, which in most cases also increases its regeneration [16,24,27,28].…”

Section: Discussionmentioning

confidence: 99%

“…Anthracyclines can enter the water system from various sources: via hospital wastewater, urine from patients, and as industrial waste [4][5][6]. Even in low concentrations, pharmaceuticals are cytotoxic, teratogenic, genotoxic, and carcinogenic [7,8]. Moreover, they can accumulate via biomagnification in aquatic and terrestrial organisms, or they can initiate a cascade of free radical reactions whose products are the highly toxic hydrogen peroxide and hydroxyl radical [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Rybczyńska‐Tkaczyk

2021

Molecules

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The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of B. adusta CCBAS 930. The activity of oxidoreductases: versatile peroxidases (VP), superoxide dismutase (SOD), catalase (CAT), and glucose oxidase (GOX), and the levels of phenolic compounds (PhC) and free radicals (SOR) were determined during the biotransformation of anthracyclines by B. adusta strain CCBAS 930. Moreover, the phytotoxicity (Lepidium sativum L.), biotoxicity (MARA assay), and genotoxicity of anthracyclines were evaluated after biological treatment. After 120 h, more than 90% of anthracyclines were removed by the immobilized mycelium of B. adusta CCBAS 930. The effective biotransformation of anthracyclines was correlated with detoxification and reduced genotoxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Rybczyńska‐Tkaczyk

2021

Molecules

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“…This is possible as a result of extracellular non-specific enzymatic complexes (including the laccases) which are secreted predominantly in extracellular form. Considering this, many researchers have studied the WRF and have proved their capacity to degrade numerous organic compounds, including emerging contaminants such as pesticides, industrial chemicals, dyes, and pharmaceuticals [160][161][162][163].…”

Section: Degradation Of Pharmaceutical Productsmentioning

confidence: 99%

Laccases—Versatile Enzymes Used to Reduce Environmental Pollution

et al. 2022

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The accumulation of waste and toxic compounds has become increasingly harmful to the environment and human health. In this context, the use of laccases has become a focus of interest, due to the properties of these versatile enzymes: low substrate specificity, and water formation as a non-toxic end product. Thus, we begin our study with a general overview of the importance of laccase for the environment and industry, starting with the sources of laccases (plant, bacterial and fungal laccases), the structure and mechanism of laccases, microbial biosynthesis, and the immobilization of laccases. Then, we continue with an overview of agro-waste treatment by laccases wherein we observe the importance of laccases for the biodisponibilization of substrates and the biodegradation of agro-industrial byproducts; we then show some aspects regarding the degradation of xenobiotic compounds, dyes, and pharmaceutical products. The objective of this research is to emphasize and fully investigate the effects of laccase action on the decomposition of lignocellulosic materials and on the removal of harmful compounds from soil and water, in order to provide a sustainable solution to reducing environmental pollution.

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“…As in municipal wastewater, wastewater treatment from healthcare facilities can be performed by conventional chemical (e.g., coagulation) [ 71 ], and biological processes—where nitrification [ 52 ] predominates. In addition, research can be observed in various innovative processes such as the applicability of the enzymes themselves [ 72 ] or their combination with a root treatment plant [ 63 ], the combination of activated sludge using vermifiltration [ 65 ], the applicability of wood-destroying fungi [ 20 ], or various modifications of nanomaterials, sorbents and related e.g., photocatalysis ( Table 5 ) [ 61 , 73 ].…”

Section: Innovative Processes Efficient In the Treatment Of Wastewater From Healthcare Facilitiesmentioning

confidence: 99%

Hospital Wastewater—Source of Specific Micropollutants, Antibiotic-Resistant Microorganisms, Viruses, and Their Elimination

et al. 2021

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Municipal wastewaters can generally provide real-time information on drug consumption, the incidence of specific diseases, or establish exposure to certain agents and determine some lifestyle consequences. From this point of view, wastewater-based epidemiology represents a modern diagnostic tool for describing the health status of a certain part of the population in a specific region. Hospital wastewater is a complex mixture of pharmaceuticals, illegal drugs, and their metabolites as well as different susceptible and antibiotic-resistant microorganisms, including viruses. Many studies pointed out that wastewater from healthcare facilities (including hospital wastewater), significantly contributes to higher loads of micropollutants, including bacteria and viruses, in municipal wastewater. In addition, such a mixture can increase the selective pressure on bacteria, thus contributing to the development and dissemination of antimicrobial resistance. Because many pharmaceuticals, drugs, and microorganisms can pass through wastewater treatment plants without any significant change in their structure and toxicity and enter surface waters, treatment technologies need to be improved. This short review summarizes the recent knowledge from studies on micropollutants, pathogens, antibiotic-resistant bacteria, and viruses (including SARS-CoV-2) in wastewater from healthcare facilities. It also proposes several possibilities for improving the wastewater treatment process in terms of efficiency as well as economy.

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Potential of enzymatic process as an innovative technology to remove anticancer drugs in wastewater

Cited by 38 publications

References 60 publications

Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Laccases—Versatile Enzymes Used to Reduce Environmental Pollution

Hospital Wastewater—Source of Specific Micropollutants, Antibiotic-Resistant Microorganisms, Viruses, and Their Elimination

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