Potential of Long Non- coding RNA Molecules in Dia gnosis of Tumors

Gromesová, Barbora; Kubaczková,; Bollová, Božena; Sedlaříková, Lenka; Ševčı́ková, Sabina

doi:10.14735/amko201620

Cited by 4 publications

(2 citation statements)

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“…The ncRNAs that have occupied a vast majority of chromosomes are involved in many biological processes and have been increasingly seen as important transcriptional regulators. Initially, they were considered “junk genes” that did not encode proteins; then, they were gradually discovered to play an important regulatory role in various biological processes 8 , 9 , 10 , 11 , 12 , 13 , 14 and perhaps as a regulator of the innate immune cell development and inflammatory gene expressions, biomarkers, and therapeutic targets for liver fibrosis or tumors, particularly in the process of tumor occurrence and development. This could be attributed to the intricate molecular mechanism between the lncRNAs and the other genes, which have rapidly become star molecules in the field of genetic research, particularly in the study of the correlation between lncRNAs and tumors.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

et al. 2021

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Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip, next-generation sequencing, and/or other methods in recent years, which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth, invasion, and metastasis of various types of human cancers, including hepatocellular carcinoma (HCC), which is an aggressive, highly malignant, and invasive tumor, and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new molecular-targeted therapies, the diagnosis, treatment, and prognosis of HCC will be considerably improved. Therefore, this review is expected to provide recommendations and directions for future lncRNA research for HCC.

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Section: Introductionmentioning

confidence: 99%

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

et al. 2021

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“…Long non-coding RNAs are linear RNAs that contain over 200 nucleotides in length (Chen et al, 2014). It accounts for about 95% of the total RNA, is widely distributed in the nucleus and cytoplasm and transcribed in eukaryotic cells (Gromesová et al, 2016). LncRNA played important roles in regulating gene expression in cells (Beermann et al, 2016;Fabbri et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA MRUL Contributes to Osteosarcoma Progression Through the miR-125a-5p/FUT4 Axis

et al. 2020

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Osteosarcoma (OS) originates in the skeletal system and has a rising global incidence. Long Non-coding RNAs (lncRNAs) are key regulators of human cancers development and progression. However, their roles in the development of OS are not well understood. This research aimed to investigate the effect of a long non-coding RNA (lncRNA), MRUL, on OS and revealed its potential molecular mechanisms. The bioinformatics analysis demonstrated that lncRNA MRUL was involved in regulating nucleic acid-templated transcription, cellular macromolecule biosynthetic process, immune response, and inflammatory response. In this work, the expression of lncRNA MRUL was detected by quantitative real-time polymerase chain reaction (qRT-RCR) in both cancer tissues and cell lines. We found that lncRNA MRUL was up-regulated in cancer tissues and cell lines. Functional experiments showed that knockdown of lncRNA MRUL inhibited OS cell proliferation, and metastasis. At the same time, we found that lncRNA MRUL interacted with miR-125a-5p to suppress FUT4 expression. Moreover, inhibition of miR-125a-5p abrogated the biological roles of lncRNA MRUL knockdown on OS cell proliferation, migration, and invasion. In conclusion, these results demonstrated that OSupregulated lncRNA MRUL promoted cell proliferation, and metastasis via negatively regulating miR-125a-5p, and imply that lncRNA MRUL may be a potential biomarker for OS.

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ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma

Lin

Ding

et al. 2018

Cancer Medicine

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Rho GTPase‐activating protein 42 was identified as an inhibitor of RhoA to maintain normal blood pressure homeostasis. However, the effect of ARHGAP42 in promoting cell malignancy in nasopharyngeal carcinoma is demonstrated in this study. Microarray and real‐time quantitative PCR were used for a mRNA profiling of ARHGAP42 in nasopharyngeal primary and metastatic carcinoma tissues. Western blot and immunohistochemical staining were used for detecting the expression of ARHGAP42 protein in nasopharyngeal carcinoma tissues and cell lines. The overexpression and silence experiments of ARHGAP42 were performed in NPC cell lines using siRNA and expressive plasmid for evaluating cancer cell migration and invasion in vitro. Real‐time quantitative PCR, western blot, and transwell test were employed for with the function of ARHGAP42 and its antisense lncRNA uc010rul. We confirmed the elevated expression of ARHGAP42 in metastatic NPC tissues of mRNA and protein for the first time. Immunohistochemical analysis indicated that NPC patients with highly ARHGAP42 expression were significantly associated with shorter metastasis‐free survival. Knockdown of ARHGAP42 resulted in significant inhibition of nasopharyngeal cancer cell migration and invasion in vitro, and the overexpression of ARHGAP42 showed the opposite effects. In addition, the silence of uc010rul resulted in ARHGAP42 expression decrease and significant inhibition of nasopharyngeal cancer cell migration and invasion. High expression of ARHGAP42 is associated with poor metastasis‐free survival of nasopharyngeal carcinoma patients. ARHGAP42 promotes migration and invasion of nasopharyngeal carcinoma cells in vitro; the antisense lncRNA may be involved in this effect.

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Potential of Long Non- coding RNA Molecules in Dia gnosis of Tumors

Cited by 4 publications

References 0 publications

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

Long Non-coding RNA MRUL Contributes to Osteosarcoma Progression Through the miR-125a-5p/FUT4 Axis

ARHGAP42 promotes cell migration and invasion involving PI3K/Akt signaling pathway in nasopharyngeal carcinoma

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