Potential of Metal Complexes for the Treatment of Cancer: Current Update and Future Prospective

Yadav, Shipra

doi:10.1002/9781119640929.ch7

Cited by 5 publications

(4 citation statements)

References 98 publications

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“…Since the discovery of Cis platin, which greatly influenced the antitumor clinical practice, several other platinum-based metallodrugs have been designed and proved to possess a great effectiveness against several tumors [ 39 , 40 ]. However, these molecules exhibited, as well, a number of disadvantages and undesired effects in treated patients [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Novel Au Carbene Complexes as Promising Multi-Target Agents in Breast Cancer Treatment

et al. 2022

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Over the past decade, metal complexes based on N-heterocyclic carbenes (NHCs) have attracted great attention due to their wide and exciting applications in material sciences and medicinal chemistry. In particular, the gold-based complexes are the focus of research efforts for the development of new anticancer compounds. Literature data and recent results, obtained by our research group, reported the design, the synthesis and the good anticancer activity of some silver and gold complexes with NHC ligands. In particular, some of these complexes were active towards some breast cancer cell lines. Considering this evidence, here we report some new Au-NHC complexes prepared in order to improve solubility and biological activity. Among them, the compounds 1 and 6 showed an interesting anticancer activity towards the breast cancer MDA-MB-231 and MCF-7 cell lines, respectively. In addition, in vitro and in silico studies demonstrated that they were able to inhibit the activity of the human topoisomerases I and II and the actin polymerization reaction. Moreover, a downregulation of vimentin expression and a reduced translocation of NF-kB into the nucleus was observed. The interference with these vital cell structures induced breast cancer cells’ death by triggering the extrinsic apoptotic pathway.

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Section: Discussionmentioning

confidence: 99%

Novel Au Carbene Complexes as Promising Multi-Target Agents in Breast Cancer Treatment

et al. 2022

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“…21,[69][70][71] According to these studies, prospective copper coordination compounds may be more effective anticancer agents than platinum-based therapies, with less toxicity to healthy cells and the possibility to sidestep the chemo-resistance inherent with repeated platinum drug administration. [72][73][74] Several copper bis(thiosemicarbazone) conjugates have shown promising anticancer properties. [75][76][77][78] Cu 2+ (atsm) is one of these complexes that retains its bonded metal in a reductive intracellular environment.…”

Section: Chelators and Ionophores In Copper Transportmentioning

confidence: 99%

“…21,69–71 According to these studies, prospective copper coordination compounds may be more effective anticancer agents than platinum-based therapies, with less toxicity to healthy cells and the possibility to sidestep the chemo-resistance inherent with repeated platinum drug administration. 72–74…”

Section: Chelators and Ionophores In Copper Transportmentioning

confidence: 99%

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

et al. 2023

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“…Chemotherapy is one of the most commonly used and effective strategies for clinical cancer treatment. − However, chemotherapy is often hindered by poor drug selectivity and high side effects. − Therefore, it is urgently needed to develop drugs with lower toxic and higher curative effect, which may be of great importance in clinical applications. In cancer cells, thioredoxin reductase (TrxR) is highly overexpressed − to maintain intracellular redox homeostasis and promote malignant tumor survival. , Designing drugs that inhibit TrxR activity is a promising approach to achieve highly effective cancer chemotherapy. − Although a number of TrxR inhibitors are known, − the selectivity is generally low.…”

Section: Introductionmentioning

confidence: 99%

Selenium Atom-Polarization Effect Determines TrxR-Specific Recognition of Metallodrugs

et al. 2022

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Thioredoxin reductase (TrxR) is highly overexpressed in cancer cells to promote malignant tumor survival. Designing drugs that inhibit TrxR activity is a promising approach to achieve highly effective cancer chemotherapy. However, the selectivity of TrxR inhibitors continue to be a challenge for scientists. In this work, we demonstrate a new strategy to selectively inhibit TrxR through constructing electrophilic center −N−Se(δ + )−N− by using the polarization effect of the selenium atom. The constructed electrophilic center interacts noncovalently with the active motif of TrxR to avoid the interference of other residues in human tissues, thereby selectively inhibiting intracellular TrxR activity. Computational and experimental analysis confirms that the formed electrophilic selenium center preferred to attack the SeC residues in the redox active center of TrxR at the 498 site through strong noncovalent interactions. Both in vitro and in vivo experimental results confirmed that this strategy can significantly improve the anticancer effect. This study may provide a novel route to design highly effective and selective chemotherapeutic drugs.

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Potential of Metal Complexes for the Treatment of Cancer: Current Update and Future Prospective

Cited by 5 publications

References 98 publications

Novel Au Carbene Complexes as Promising Multi-Target Agents in Breast Cancer Treatment

Novel Au Carbene Complexes as Promising Multi-Target Agents in Breast Cancer Treatment

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

Selenium Atom-Polarization Effect Determines TrxR-Specific Recognition of Metallodrugs

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