Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs

Rubio-Hernández, Mercedes; Alcolea, Verónica; Pérez‐Silanes, Silvia

doi:10.1016/j.actatropica.2022.106547

Cited by 9 publications

(7 citation statements)

References 134 publications

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“…Among these, selenocyanates compound 13 stood out, demonstrating an IC 50 value of 0.085 � 0.004 μM against the trypomastigote form. [157] Mathias et al (2022) synthesized novel nitropyrrole analogs, with compound 14 identified as a standout candidate, exhibiting an EC 50 value of 3.6 � 1.8 μM against the amastigote form of Vero host cells. [158] In 2023, Souza et al delved into Metal-BZN complexes, surpassing the efficacy of BZN alone against T. cruzi.…”

Section: Synthesized Derivatives For the Treatment Of Chagas Diseasementioning

confidence: 99%

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Alternative Approaches for the Treatment of Chagas Disease

Chaudhary,

Rajge,

Khandale

et al. 2024

ChemistrySelect

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Chagas disease (CD), or American trypanosomiasis, caused by the parasitic protozoa Trypanosoma cruzi, is a substantial global health burden. This comprehensive review explored the multifaceted landscape of CD treatment, providing a historical perspective on the development and discontinuation of benznidazole (BNZ) and nifurtimox (NF), the primary medications. Efforts towards a pediatric version of BZN in Brazil address demographic‐specific treatments, while concerns over drug resistance prompt the exploration of alternative medications like Amiodarone, Allopurinol, Posaconazole, Ravuconazole, and Fexinidazole, which were clinically tested as antichagasic drugs. In recent years, some of the synthesized derivative (1,3‐thiazoles, 4‐thiazolidinones, 2‐styrylquinolines, imidazole‐containing nitrophthalazine, and some others) were found to better activity as compared to standard drug. Traditional herbal alternatives (Resveratrol, curcumin, 1,8‐cineole, β‐pinene, and some others) rooted in traditional practices show promise, with various plant extracts exhibiting anti‐parasitic properties. The frontier of nanomedicine unfolds with studies on solid nanomedicines, PLA‐nanoparticles, ZIF‐8, BNZ carriers, and PLGA nanoparticles, showcasing improved drug delivery systems and controlled release mechanisms. The absence of a definitive vaccine accentuates ongoing research in recombinant antigens, peptide‐based vaccines, and nanoparticle formulations, with notable candidates like TcG1, TcG2, TcG4, MASPpep‐KLH, adenovirus vectors, Tc24 protein, and integrin activators. A novel strategy combining a recombinant protein vaccine with low dose BZN treatment presents promising results in a mouse model, emphasizing the urgency for further research and potential advancements in CD therapeutics.

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Section: Synthesized Derivatives For the Treatment Of Chagas Diseasementioning

confidence: 99%

“…developed a novel anti‐Chagas drug, incorporating sulfur‐selenium isosteric replacement into compounds featuring semicarbazones, quinones, and cyanates. Among these, selenocyanates compound 13 stood out, demonstrating an IC 50 value of 0.085±0.004 μM against the trypomastigote form [157] . Mathias et al .…”

Section: Treatmentmentioning

confidence: 99%

Alternative Approaches for the Treatment of Chagas Disease

Chaudhary,

Rajge,

Khandale

et al. 2024

ChemistrySelect

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“…Simple organothiocyanates and organoselenocyanates, as depicted in Figure 1 , have been reported to display a broad range of biological activities, ranging from chemoprevention [ 17 ] and antiproliferative activity against cancer cells [ 18 ] to peroxide scavenging [ 19 ] and treatment of Chagas disease [ 20 , 21 , 22 ]. Additionally, these compounds can be easily converted to other functional groups or employed in synthetic transformations [ 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Selenonium Salt as a Catalyst for Nucleophilic Substitution Reactions in Water: Synthesis of Thiocyanites and Selenocyanates

2023

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Organothiocyanates and selenocyanates are valuable compounds, both in terms of functional group interconversion and due to their biological activities. In this contribution, we report the synthesis of a series of these important substances in a mixture of water and dimethyl carbonate (20/1 proportion) using potassium thio- or selenocyanates salts and organic bromides. The key to the effectiveness of the reaction is a chalcogen bond interaction between a selenonium salt catalyst and the organic substrate.

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“…These compounds exhibit interesting physical, chemical, and biological properties which motivate studies from synthetic organic chemists and the pharmaceutical industry [13]. In addition, due to their unique physical and chemical properties, many of these compounds have been used as versatile building blocks in the synthesis of complex organic molecules, biologically active compounds, pharmaceuticals, and natural products [14][15][16]. From the viewpoint of biological activities, organochalcogen compounds are known by their antioxidant [17,18], antitumoral [19][20][21], antimicrobial [22,23], and anti-inflammatory activities [24].…”

Section: Introductionmentioning

confidence: 99%

“…Catalysts 2023, 13, 1300 2 of 36 synthesis of complex organic molecules, biologically active compounds, pharmaceuticals, and natural products [14][15][16]. From the viewpoint of biological activities, organochalcogen compounds are known by their antioxidant [17,18], antitumoral [19][20][21], antimicrobial [22,23], and anti-inflammatory activities [24].…”

Section: Introductionmentioning

confidence: 99%

Recent Approaches in Transition Metal-Catalyzed Chalcogenative Heteroannulation of Alkenes and Alkynes

Gutterres,

Anjos,

Santos

et al. 2023

Catalysts

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Organochalcogen-bearing heterocycles are important scaffolds in compounds under the spotlight of scientific interest in optoelectronic fields and for biological applications. The use of transition metals has been a versatile and reliable way to carry out the synthesis of these molecules efficiently, delivering products in high yields and with a wide functional diversity. In the last 10 years, many classes of heterocycles have been synthesized under the cyclization reaction of acyclic alkenes and alkynes with the incorporation of a chalcogen atom on its structure. Transition metal catalysts including Cu, Co, Pd, Ni, In, Ag, and Fe salts have been used in the development of new methodologies, the expansion of substrate scope, and mechanistic studies. This review provides an overview of these recent approaches with the aim of being a useful resource for interested researchers in this area.

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Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs

Cited by 9 publications

References 134 publications

Alternative Approaches for the Treatment of Chagas Disease

Alternative Approaches for the Treatment of Chagas Disease

Selenonium Salt as a Catalyst for Nucleophilic Substitution Reactions in Water: Synthesis of Thiocyanites and Selenocyanates

Recent Approaches in Transition Metal-Catalyzed Chalcogenative Heteroannulation of Alkenes and Alkynes

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