Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes

Abstract

Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and HbA1c levels were independently associated with NAFLD development in individuals without diabetes. Receiver operating characteristic (ROC) analysis identified the optimal cutoff point of ALT (> 19 IU/ml) with AUC = 0.731, 95% CI 0.653–0.809. On the other hand, the optimal cutoff point of HbA1c was identified to be > 5.1% with AUC = 0.665, 95% CI 0.581–0.750. Conclusions Early identification of NAFLD among subjects without diabetes is crucial. In this study, ALT and HbA1c cutoff values had been identified, so we suggest that inclusion of both HbA1c and ALT levels may have significant implications for prediction of NAFLD among individuals without diabetes.

Luteolin loaded on zinc oxide nanoparticles ameliorates non-alcoholic fatty liver disease associated with insulin resistance in diabetic rats via regulation of PI3K/AKT/FoxO1 pathway

“…Moreover, it deranged insulin inhibition of hepatic glucose production and affected insulin sensitivity in muscle and adipose tissue. 9,45 Consequently, the obtained results revealed that feeding rats with HFD and injection with STZ impaired glucose homeostasis, lipid metabolism, and tissue insulin sensitivity. This was evident via the higher levels of blood glucose (hyperglycemia) and insulin (hyperinsulinemia), and the increased value of HOMA-IR confirming the insulin resistance status in both HFD (obese) and HFD/STZ (diabetic) rats.…”

“…Moreover, it deranged insulin inhibition of hepatic glucose production and affected insulin sensitivity in muscle and adipose tissue. 9 , 45 …”

Racial/ethnic and gender disparity in the severity of NAFLD among people with diabetes or prediabetes

“…These results highlight the importance of glycemic control in reducing the odds of severe NAFLD. Recent studies in several countries have found an association between HbA1c and NAFLD in general or normoglycemic populations ( Tanaka et al, 2019 ; Masroor and Haque, 2021 ; Naguib and Kassab, 2021 ), but most have not evaluated the association within patients with prediabetes or diabetes. One of these previous studies found that the association held after controlling for diabetes status, consistent with our findings ( Masroor and Haque, 2021 ).…”