Potential Role of Haematococcus Pluvialis Against Diabetes Induced Oxidative Stress and Inflammation in Rats

El-Baz, Farouk; Aly, Hanan F.; Khalil, Wagdy K. B.; Al, Gamila H; Hafiz, Naglaa A.; Saad, Safaa A.

doi:10.22159/ajpcr.2017.v10i1.15073

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…These findings are consistent with the results of a previous study, in which 7-week administration of green coffee bean extract could decrease FPG, profile lipid, and blood pressure and improved adiponectin level and HOMA-IR index [26]. In addition, diabetic rats treated with Haematococcus pluvialis extract showed significant improvement in oxidative stress, enhanced antioxidant status, and inflammatory cytokines induced by hyperglycemia in diabetic rats [27]. These results imply that the treatment with puguntano may improve glucose metabolism and ameliorate insulin resistance and inflammation through adiponectin and AdipoR in patients with T2DM.…”

Section: Discussionsupporting

confidence: 92%

The Effect of Puguntano (Curanga Fel-Terrae [Lour.]) Extract on Adiponectin Receptor (Adipor) in Rats With Type 2 Diabetes Mellitus

Lindarto

Machrina

Syafril

et al. 2019

Asian J Pharm Clin Res

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Objective: This study aimed to determine whether the antidiabetic effects of puguntano (Curanga fel-terrae [Lour.]) extract involve anti-inflammatory effects mediated through adiponectin receptors (AdipoRs). Methods: Type 2 diabetes mellitus (T2DM) Wistar rats were induced by a combination of high-fat diet for 5 weeks and injection small dose streptozotocin 30 mg/kg bw/rat. This study was conducted in 48 T2DM rats, which were randomly assigned into two weight-matched groups (n=24, each). Only the treatment group received 0.2 mg/g bw of puguntano extract suspension through oral for 10 days. The clinical characteristics of T2DM and AdipoR were assessed before and after the treatment period. Results: The treatment group demonstrated significantly lower body weight, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) but higher AdipoR than the control group (all, p<0.001). Furthermore, there were also negative correlations between AdipoR to body weight and HOMA-IR (all, p<0.05). Conclusion: Our data suggest that puguntano could improve glucose metabolism and ameliorate insulin resistance and have anti-inflammatory effects mediated through AdipoR in T2DM.

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Section: Discussionsupporting

confidence: 92%

The Effect of Puguntano (Curanga Fel-Terrae [Lour.]) Extract on Adiponectin Receptor (Adipor) in Rats With Type 2 Diabetes Mellitus

Lindarto

Machrina

Syafril

et al. 2019

Asian J Pharm Clin Res

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“…It was indicated that H. pluvialis species is well known for its high content of the strong antioxidant astaxanthin (ATX) that can be protective against several kinds of oxidative damage. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Astaxanthin-Rich Haematococcus pluvialis Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2

Baz¹,

Hussein²,

Jaleel³

et al. 2018

Adv Pharm Bull

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Purpose: Aging is associated with hepatic morphological and physiological deterioration due to the accumulation of endogenous and exogenous free radicals and the resultant oxidative stress. The present study aims to investigate the effect of Haematococcus pluvialis microalgae on hepatic changes associated with D-galactose (D-Gal)-induced aging in rats.Methods: Aging was induced in rats by daily intraperitoneal injection of D-Gal (200 mg/kg/day) for eight consecutive weeks. D-Gal-injected rats were treated by astaxanthin (ATX)-rich H. pluvialis biomass, its carotenoid and polar fractions for two weeks. Twenty four hours after the last dose, blood samples were collected and the liver tissues were isolated for further biochemical and histopathological examinations.Results: D-Gal induced aging was associated with an elevation in serum liver function parameters, hepatic oxidative stress biomarkers viz., catalase (CAT), glutathione transferase (GST) and myeloperoxidase (MPO), as well as decreased expression of nuclear factor like-2 (Nrf2). Moreover, induction of aging exhibited an elevation of hepatic inflammatory cytokine; interleukin-6 (IL-6) and its modulator; nuclear factor Kappa B (NF-KB). However, treatment of D-Gal injected rats with ATX-rich H. pluvialis restored the serum liver function parameters as well as hepatic CAT, GST and MPO levels with an elevated expression of Nrf2. Treatment with ATX-rich H. pluvialis was also accompanied with a decrease in hepatic levels of NF-KB and IL-6. Histopathological examination emphasized all the previous results. Similarly, all trans-astaxanthin showed high affinity towards Nrf2 with -7.93 kcal/mol estimated free energy of binding as well as moderate affinities towards IL-6 and NF-KB through a docking study.Conclusion: ATX-rich H. pluvialis showed beneficial effects by ameliorating the hepatic changes associated with D-Gal induced aging in rats due to its modulatory role of the Nrf2/Keap pathway.

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“…It is significant that a fructose feed of 10 g/d influenced such chronic changes in serum creatinine and increased urine excretion. Oxidative stress helps to accelerate pathological conditions in diabetes [22][23][24] and promotes the rate of protein glycation [25,26]. So, we attempted to study the effect of probiotics and glycation inhibitor AMG on ROS formation, antioxidant status and tissue fluorescence.…”

Section: Discussionmentioning

confidence: 99%

Glycation Inhibitors and Probiotics Can Ameliorate the Changes Caused by High Fructose Feed

Patil

Jagdale

Nalawade

et al. 2018

Int J Pharm Pharm Sci

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Objective: To evaluate the use of protein glycation inhibitors and probiotics to ameliorate secondary complications in diabetes and to improve gut microbiota respectively in high fructose fed Wistar rat. Methods:The study was conducted on male Wistar rats for 7 d. Blood glucose levels in oral glucose tolerance test (OGTT) were measured using glucometer, serum parameters were analyzed using commercial kits, antioxidant status was evaluated by measuring superoxide dismutase (SOD) and catalase (CAT) levels, total reactive oxygen species were estimated using a fluorescent 2', 7'-dichlorofluorescin diacetate (DCF-DA) dye, and tissue fluorescence of liver, kidney and intestine were measured using a spectrofluorimeter.Results: OGTT pattern shows significant increase in blood glucose of fructose fed rats i.e. 154 mg/dl while, in aminoguanidine (AMG) treated and gut microbiota modulated animals it is 137 and 119 mg/dl resp. after 30 min on glucose administration. Marked reduction was found in SOD 6.37 and 11.25 U/mg of protein and catalase 186 and 65.5 U/mg of protein in liver and kidney of fructose fed animals when compared to fructose+AMG and fructose+EUGI. There is 5-6 fold significant increase in general and specific tissue fluorescence of liver and kidney, and 2.2 fold increase in liver reactive oxygen species was observed in fructose fed group as compare to control animals. Significantly higher glycation was found in intestine of fructose fed animals (general fluorescence 2.1 and specific fluorescence 3.1 AU/mg), more than that of diabetic control rats (general fluorescence 0.9 and specific fluorescence 1.6 AU/mg), represented an evidence for adverse impact of excess fructose on healthy gut. Conclusion:The use of protein glycation inhibitor and use of pre and probiotics significantly improved the serum parameters and would prevent progression to secondary complications.

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Potential Role of Haematococcus Pluvialis Against Diabetes Induced Oxidative Stress and Inflammation in Rats

Cited by 4 publications

References 24 publications

The Effect of Puguntano (Curanga Fel-Terrae [Lour.]) Extract on Adiponectin Receptor (Adipor) in Rats With Type 2 Diabetes Mellitus

The Effect of Puguntano (Curanga Fel-Terrae [Lour.]) Extract on Adiponectin Receptor (Adipor) in Rats With Type 2 Diabetes Mellitus

Astaxanthin-Rich Haematococcus pluvialis Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2

Glycation Inhibitors and Probiotics Can Ameliorate the Changes Caused by High Fructose Feed

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