Potential role of microbiome in oncogenesis, outcome prediction and therapeutic targeting for head and neck cancer

Orlandi, Ester; Iacovelli, Nicola Alessandro; Tombolini, Vincenzo; Rancati, T.; Polimeni, Antonella; Cecco, Loris De; Valdagni, Riccardo; Felice, Francesca De

doi:10.1016/j.oraloncology.2019.104453

Cited by 52 publications

(49 citation statements)

References 72 publications

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“…In this scenario, several species have been strongly correlated with oral carcinoma, such as Capnocytophaga gingivalis, Fusobacterium sp., Streptococcus sp., Peptostreptococcus sp., Porphyromonas gingivalis and Prevotella sp., due to the fact that these bacteria may promote inflammation, cell proliferation and the production of some oncogenic substances (90). Recent findings have shown that the evaluation of oral microbiota and microbiome may provide important information on oral cancer oncogenesis, outcome prediction and therapeutic response (including immunotherapy) (198,199). In addition, thanks to the new high-throughput molecular technologies it was possible to define the precise composition and gene expression (micro-biome) of oral bacteria in OSCC patients and normal controls identifying specific strains associated with an increased risk of OSCC development (1,200).…”

Section: Discussionmentioning

confidence: 99%

Association of oral dysbiosis with oral cancer development (Review)

et al. 2020

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Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer. Numerous risk factors mainly related to unhealthy habits and responsible for chronic inflammation and infections have been recognized as predisposing factors for oral carcinogenesis. Recently, even microbiota alterations have been associated with the development of human cancers. In particular, some specific bacterial strains have been recognized and strongly associated with oral cancer development (Capnocytophaga gingivalis, Fusobacterium spp., Streptococcus spp., Peptostreptococcus spp., Porphyromonas gingivalis and Prevotella spp.). Several hypotheses have been proposed to explain how the oral microbiota could be involved in cancer pathogenesis by mainly paying attention to chronic inflammation, microbial synthesis of cancerogenic substances, and alteration of epithelial barrier integrity. Based on knowledge of the carcinogenic effects of dysbiosis, it was recently suggested that probiotics may have anti-tumoral activity. Nevertheless, few data exist with regard to probiotic effects on oral cancer. On this basis, the association between the development of oral cancer and oral dysbiosis is discussed focusing attention on the potential benefits of probiotics administration in cancer prevention.

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Section: Discussionmentioning

confidence: 99%

Association of oral dysbiosis with oral cancer development (Review)

et al. 2020

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“…1). S. mutans was used as a negative control since S. mutans has not been shown to have an obvious effect on oral tumor progression (Gholizadeh et al 2016;Orlandi et al 2019).…”

Section: P Gingivalis Promotes Tumormentioning

confidence: 99%

Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment

Wen

et al. 2020

J Dent Res

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Increasing evidence has revealed a significant association between microorganisms and oral squamous cell carcinoma (OSCC). Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, is considered an important potential etiologic agent of OSCC, but the underlying immune mechanisms through which P. gingivalis mediates tumor progression of the oral cancer remain poorly understood. Our cohort study showed that the localization of P. gingivalis in tumor tissues was related to poor survival of patients with OSCC. Moreover, P. gingivalis infection increased oral lesion multiplicity and size and promoted tumor progression in a 4-nitroquinoline-1 oxide (4NQO)–induced carcinogenesis mouse model by invading the oral lesions. In addition, CD11b+ myeloid cells and myeloid-derived suppressor cells (MDSCs) showed increased infiltration of oral lesions. Furthermore, in vitro observations showed that MDSCs accumulated when human-derived dysplastic oral keratinocytes (DOKs) were exposed to P. gingivalis, and CXCL2, CCL2, interleukin (IL)–6, and IL-8 may be potential candidate genes that facilitate the recruitment of MDSCs. Taken together, our findings suggest that P. gingivalis promotes tumor progression by generating a cancer-promoting microenvironment, indicating a close relationship among P. gingivalis, tumor progression of the oral cancer, and immune responses.

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“…Higher doses to jaw bone bear a higher risk of developing ORN. Also, the role of the oral microbiome in the development, treatment response, and treatment toxicity in patients with HNC needs to be further explored (Orlandi et al, 2019).…”

Section: Head and Neck Cancermentioning

confidence: 99%

“…As mentioned, the oral microbiome might play a role in the development, treatment response, and treatment toxicity in patients with HNC (Gaetti‐Jardim et al, 2018; Orlandi et al, 2019). In this respect, it is important to note that Schuurhuis, Stokman, et al (2016) found an almost immediate effect on the composition of the oral flora after the elimination of oral foci of infection, with a decrease of periodontal pathogens.…”

Section: Head and Neck Cancermentioning

confidence: 99%

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

et al. 2020

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An oral focus of infection is defined as a pathologic process in the oral cavity that does not cause major infectious problems in healthy individuals, but may lead to severe local or systemic inflammation under certain circumstances (Nabil & Samman, 2011; Sennhenn-Kirchner et al., 2009). Frequently observed potential oral foci of infection include caries profunda, periodontal disease, periapical problems, (partially) impacted or partially erupted teeth not fully covered by bone or showing radiolucency, cysts, non-vital pulps, and ulcerations (Ben

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Potential role of microbiome in oncogenesis, outcome prediction and therapeutic targeting for head and neck cancer

Cited by 52 publications

References 72 publications

Association of oral dysbiosis with oral cancer development (Review)

Association of oral dysbiosis with oral cancer development (Review)

Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

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