Potential role of soluble CD40 receptor in chronic inflammatory diseases

Wagner, A.H.; Klersy, A.; Sultan, C.S.; Hecker, M.

doi:10.1016/j.bcp.2023.115858

Biochemical Pharmacology

2023

DOI: 10.1016/j.bcp.2023.115858

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Potential role of soluble CD40 receptor in chronic inflammatory diseases

A.H. Wagner,

A. Klersy,

C.S. Sultan

et al.

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Cited by 4 publications

References 107 publications

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Frequency of CD40‐1C>T polymorphism (rs1883832) and association with response to treatment in children with primary immune thrombocytopenia

Ahmed,

Abdelkreem,

Hamed

et al. 2024

Pediatric Blood & Cancer

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Objectives: To investigate whether (cluster of differentiation) CD40‐1C>T (rs1883832) contributes to predisposition and treatment response of primary immune thrombocytopenia (pITP) in children.Methods: A case–control study that included 100 children with newly diagnosed pITP and 50 age‐ and sex‐matched healthy controls. CD40 rs1883832 was genotyped using TaqMan allele discrimination real‐time polymerase chain reaction (PCR). Patients were categorized into responders and non‐responders according to their response to corticosteroids and thrombopoietin‐receptor agonists (TPO‐RA) at 3‐month intervals.Results: The genotypic distribution of the CD40 rs1883832 was significantly different among cases and controls (CC 48% vs. 30%; CT 44% vs. 42%; TT 8% vs. 28%; p = .003). Compared with controls, children with newly diagnosed pITP had significantly higher C allele frequency (70% vs. 51%; odds ratio [OR] 2.2, 95% confidence interval [CI]: 1.3–3.8; p = .001). The association between C allele frequency and pITP risk was evident in females (OR 4.3, 95% CI: 2.1–8.8; p < .001), but not in males (OR 0.9, 95% CI: 0.4–2.1; p = .822). Compared with responders, the C allele frequency was significantly higher among non‐responders to corticosteroids (87% vs. 66%; OR 3.4, 95% CI: 1.2–11.7; p = .012), but not to TPO‐RA (92% vs. 85%; OR 2, 95% CI: 0.2–107; p = .550).Conclusion: CD40 rs1883832 polymorphism may contribute to predisposition and response to upfront corticosteroids therapy of pediatric pITP. These findings improve our understanding of the compound pathophysiology of ITP, suggest important clinical potentials, and open the door for further research on the mechanistic role of CD40 rs1883832 in ITP development and progression.

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Frequency of CD40‐1C>T polymorphism (rs1883832) and association with response to treatment in children with primary immune thrombocytopenia

Ahmed,

Abdelkreem,

Hamed

et al. 2024

Pediatric Blood & Cancer

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Genetic association and drug target exploration of inflammation-related proteins with risk of major depressive disorder

Sun,

Cao,

Liu

et al. 2025

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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The role of soluble immune checkpoint molecules in hematologic malignancies (review)

Glazanova,

Pavlova,

Kuzmich

et al. 2024

Mol Med Rus

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Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information presented in current literature on the role of soluble ICs (sICs) in the development of hematological neoplasia. Material and methods. The review includes data from foreign and domestic articles published in PubMed over the past 15 years, which are devoted to the role of soluble IC molecules in the pathogenesis of hematologic malignancies. Results. The development of lymphoid and myeloid neoplasia is accompanied by an increase in the level of a number of soluble immunoregulatory molecules (programmed cell death protein 1 (sPD-1) and its ligands sPD-L1 and sPD-L2, cytotoxic lymphocyte antigen 4 (sCTLA-4), T-cell immunoglobulin domain and mucin domain 3 (sTIM-3), costimulatory molecules sCD86, sCD40), which is associated with a poor prognosis, shorter overall and progression-free survival of patients. The established patterns confirm the pathogenetic role of the listed soluble IC molecules in the development of malignant diseases of the blood system, as well as their significance as predictors of response to therapy and risk groups stratification. Conclusion. The presented analysis demonstrates the significant pathogenetic and prognostic role of sICs in hematological neoplasia of lymphoid and myeloid nature.

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Potential role of soluble CD40 receptor in chronic inflammatory diseases

Cited by 4 publications

References 107 publications

Frequency of CD40‐1C>T polymorphism (rs1883832) and association with response to treatment in children with primary immune thrombocytopenia

Frequency of CD40‐1C>T polymorphism (rs1883832) and association with response to treatment in children with primary immune thrombocytopenia

Genetic association and drug target exploration of inflammation-related proteins with risk of major depressive disorder

The role of soluble immune checkpoint molecules in hematologic malignancies (review)

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