Potential technique for tiny crystalline detection in lycopene-loaded SLN and NLC development

Abstract

It could be concluded that TEM is a promising method for detection of low-level crystallinity of solid nanocarriers.

Exploitation of amaranth oil fractions enriched in squalene for dual delivery of hydrophilic and lipophilic actives

“…According to several studies, it has been reported that when the drug does not exhibit its endothermic peak in the nanostructured formulations, the drug is considered to be in amorphous state (Agrawal et al, 2010;Okonogi and Riangjanapatee, 2014). Thus, it could be concluded that Hes was converted after encapsulation from crystal form to an amorphous state.…”

An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles

“…Different types of antioxidant compounds have been topically administered in the skin, such as carotenoids [9][10][11][12][13], coenzyme Q10 [14][15][16][17][18], essential oils [19][20][21], polyphenols [22][23][24][25][26], and vitamins [27][28][29][30][31]. Since only a few active ingredients are effective after topical application due to the barrier function of the skin, lipid nanoparticles have been explored as carriers to enhance bioavailability, skin penetration, and retention of the active ingredients [32][33][34].…”

Wax‐based delivery systems: Preparation, characterization, and food applications

“…Naturally occurring waxes like CRW, CLW, and BW have been approved as generally recognized as safe for direct addition to foods and have been used as solid lipid in formulation of SLN and NLC by some researchers (Asumadu-Mensah, Smith, & Ribeiro, 2013;Lacatusu et al, 2013;Mitrea, Ott, & Meghea, 2014). However, the potential of less explored waxes (PW and orange wax) in formation of an appropriate solid lipid matrix was also reported (Okonogi & Riangjanapatee, 2014;Soleimanian, Goli, Varshosaz, & Sahafi, 2018).…”

“…Ruktanonchai et al (2008) formulated SLNs using cetyl palmitate for encapsulation of γ-oryzanol as a natural antioxidant for both pharmaceutical and food applications. Other kinds of lipophilic bioactive food ingredients; β-carotene, β-sitosterol, and lycopene have been also successfully encapsulated into wax-based NLC and SLN delivery systems (Lacatusu, Badea, Ovidiu, et al, 2012;Lacatusu, Badea, Stan, et al, 2012;Okonogi & Riangjanapatee, 2014). Nanoencapsulation of lutein in CRW matrix has been reported by Lacatusu et al (2013).…”

“…Liquid lipids or oils are specifically used for production of NLCs and provide imperfections in the solid matrix that can accommodate the drugs molecules (Shah et al., 2015). Natural edible oils such as pomegranate seed oil (PSO; Soleimanian, Goli, Varshosaz, & Maestrelli, 2018; Soleimanian, Goli, Varshosaz, & Sahafi, 2018), grape seed oil (Lacatusu, Badea, Stan, & Meghea, 2012; Lacatusu, Badea, Ovidiu, Bojin, & Meghea, 2012; Manea, Ungureanu, & Meghea, 2014), squalene (Lacatusu, Badea, Ovidiu, et al., 2012; Lacatusu, Badea, Stan, et al., 2012), sea buckthorn oil and St. John's wort oil (Manea, Ungureanu, et al., 2014), fish oil (Lacatusu, Badea, Stan, et al., 2012; Lacatusu et al., 2013), raspberry oil, and rice oil (Mitrea et al., 2014; Okonogi & Riangjanapatee, 2014) have been successfully used as liquid lipid in wax‐based NLC formulations (Table 2).…”