Potential therapeutic and diagnostic applications of one-step in situ biosynthesized gold nanoconjugates (2-in-1 system) in cancer treatment

Mukherjee, Sudip; Vinothkumar, B; Prashanthi, Suthari; Bangal, Prakriti Ranjan; Sreedhar, B.; Patra, Chitta Ranjan

doi:10.1039/c2ra22299j

Cited by 65 publications

(38 citation statements)

References 56 publications

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“…Green synthesis is a non-toxic method due to very less or non-consumption of hazardous materials on the surface of nanomaterials. Biosynthesized nanoparticles by green synthesis are normally biocompatible and have more biomedical applications [6,7]. Furthermore, the phytochemical constituents of Azadirachta indica (A. indica) (neem) can block cancer growth, and they have strong reducing properties [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Palai

Mondal

Chakraborti³

et al. 2019

SN Appl. Sci.

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In this study design, the PEGylated silver decorated graphene nanocomposites (NGO-AgNPs-PEG) were successfully prepared by eco-friendly non-toxic green synthesis following a novel syn-graphenization method using the aqueous leaf extract of Azadirachta indica (A. indica) (neem) as reducing agent. The prepared Smart pH stimuli responded nanoplatform was thoroughly characterized by various analytical techniques. Since a functional nanocarrier is very essential for cancer therapy, it could quickly guide the loaded anticancer drug to the tumor site to decrease the side effect. In order to overcome the side effects of doxorubicin (DOX), an anticancer drug, it was incorporated into amino PEGylated NGO-AgNPs nanocomposites. Considering drug loading and release studies, it may be concluded that improved drug loading efficiency (218%) and more pH-responsive controlled release (following Korsmeyer-Peppas model release kinetics) of DOX from NGO-AgNPs-PEG lead to a promising nanocarrier for the anticancer drug. The cytotoxicity study results, on HaCaT cell lines, indicated DOX-loaded PEGylated functionalized nanographene oxides, as compared to free DOX, had lesser harmful effect on normal cells than cancer cells. Increased cytotoxicity was exhibited in the cancerous cells (HeLa cell lines) treated with DOX loaded PEGylated silver functionalized nanographene oxide compared to covalently conjugated NGO-DOX. So, the effective delivery and release of the anticancer drug into acidic microenvironment of the targeted tumour cells would bring out higher therapeutic efficacy than pure NGO. Such a gold standard biocompatible PEGylated silver decorated NGO theranostic nanoplatform may be an excellent nano cargo for targeted and controlled drug delivery in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Palai

Mondal

Chakraborti³

et al. 2019

SN Appl. Sci.

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“…Daizy et al [21] reported that Cassia fistula stem bark mediated Au-NPs are better hypoglycemic agents in the treatment of diabetes mellitus and its associated complications. Mukherjee et al [22] proposed that green synthesized gold nanobioconjugates using Olax Scandens leaf (Au-NPs-OX) could be used as alternative diagnostic and therapeutic approaches for cancer diseases. Kumar et al [23] reported that the physicochemical properties, biostability and blood compatibility evaluation of Au-NPs prepared from Zingiber officinale extract support its usage as vectors for the applications in drug delivery, gene delivery or as biosensors, where a direct contact with blood occurs.…”

Section: Introductionmentioning

confidence: 99%

Mulberry leaf extract mediated synthesis of gold nanoparticles and its anti-bacterial activity against human pathogens

Adavallan

Krishnakumar

2014

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Gold nanoparticles (Au-NPs) were synthesized at room temperature using Morus alba (mulberry) leaf extract as reducing and stabilizing agent. The development of plant mediated synthesis of nanoparticles is gaining importance due to its simplicity, low cost, non-toxicity, ecofriendliness, long term stability and reproducible aqueous synthesis method to obtain a selfassembly of nearly monodispersed Au-NPs. The formation and morphology of biosynthesized nanoparticles are investigated with the help of UV-Vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), atomic force microscopy (AFM), x-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) techniques. Au-NPs formation was screened by UV-Vis spectroscopy through color conversion due to surface plasmon resonance band at 538 nm for Au-NPs. DLS studies revealed that the average size of Au-NPs was 50 nm. TEM studies showed the particles to be nearly spherical with few irregular shapes and particle size ranges 15−53 nm. The AFM image clearly shows the surface morphology of the well-dispersed Au-NPs with less than 50 nm. The high crystallinity of nanoparticles is evident from bright circular spots in the selected area electron diffraction (SAED) pattern. X-ray diffraction pattern showed high purity and face-centered cubic structure of Au-NPs. The FT-IR results indicate the presence of different functional groups present in the biomolecule capping the nanoparticles. Further, biosynthesized Au-NPs show strong zone of inhibition against Vibrio cholera (gram-negative) and Staphylococcus aureus (gram-positive) whereas, chemically synthesized Au-NPs and mulberry leaf extract exhibit a fair zone of inhibition.

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“…Mukherjee and coworkers experimentally proved the nontoxic nature of these biogenic NPs in C57BL6/J female mice via various biochemical parameters along with a histopathology study of different organs. Even after successive injections of biogenic AuNPs (1 or 10 mg/kg/day) for seven days in healthy mice, no toxicity was observed (142). Moreover, it is interesting to note that in another study the same group reported that mice treated with chemically synthesized AuNPs showed broken alveolar walls with hyperplasic sinusoids as compared to the untreated or green synthesized AuNPs-treated mice (143).…”

Section: Toxicological and Immunological Aspectmentioning

confidence: 95%

Anti-cancer green bionanomaterials: present status and future prospects

Barabadi

Ovais

Shinwari

et al. 2017

Green Chemistry Letters and Reviews

186

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Cancer is one of the most common health problems responsible for outnumbered deaths worldwide. Nanomedicine plays an important role in developing alternative and more effective treatment strategies for cancer theranostics. However, the toxicity, high cost and nanoparticles (NPs) production complexity are some of the major issues that obstruct the use of existing nanomedicine. Recently, the green synthesis of biogenic NPs from plants and microbial sources has become an emerging field due to their safer, eco-friendly, simple, fast, energy efficient, lowcost and less toxic nature. Interestingly, NPs play a key role in diagnosis of tumor at the initial stage by allowing cellular visualization. Furthermore, prospective applications of green NPs include magnetically responsive drug delivery, anti-cancer activity, photo-thermal therapy and bio-imaging. The present review provides perspective on the use of anti-cancer green bionanomaterials with a focus on their present status and future prospects in the theranostics of cancer.

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Potential therapeutic and diagnostic applications of one-step in situ biosynthesized gold nanoconjugates (2-in-1 system) in cancer treatment

Abstract: Potential therapeutic and diagnostic applications of one-step in situ biosynthesized gold nanoconjugates (2in-1 system) in cancer treatment3

Cited by 65 publications

References 56 publications

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Green synthesized amino-PEGylated silver decorated graphene nanoplatform as a tumor-targeted controlled drug delivery system

Mulberry leaf extract mediated synthesis of gold nanoparticles and its anti-bacterial activity against human pathogens

Anti-cancer green bionanomaterials: present status and future prospects

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