Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine

Jokar, Assie; Masoomi, Fatemeh; Sadeghpour, Omid; Nassiri-Toosi, Mohsen; Hamedi, Shokouhsadat

doi:10.1016/s0254-6272(16)30035-8

Cited by 50 publications

(40 citation statements)

References 20 publications

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“…Terminalia chebula has a stimulating effect on the heart and is useful in the management of tachycardia and palpitations. It is known to increase the force of contraction as well as the cardiac output without having any effect on the heart rate (Jokar et al, ). The standardized myrobalan formulation known as Triphala churna, when dissolved in ethanol showed significant potential to inhibit CYP3A4 and CYP2D6 enzyme activity with IC 50 values of 119.65 ± 1.91 μg/ml and 105.03 ± 0.98 μg/ml respectively (Ponnusankar et al, ).…”

Section: Herbs Postulated To Induce Hdi With Cardiovascular Drugsmentioning

confidence: 99%

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Shaikh

Thomas

Chitlange

2020

Phytotherapy Research

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About 70% of the world population is currently using medicinal herbs as complementary or alternative medicine, which is increasing at a tremendous pace in both developed and developing countries in the last two decades (World Health Organization Medicines Strategy 2002–2005). This increase in consumer demand of medicinal herbs continues despite the rarity of scientific data to establish their safety and efficacy profile. Its popularity is also attributed to several factors, including easy availability, cost effectiveness leading to better purchasing power and general perception that they are safe. Herbs are often administered concomitantly with therapeutic drugs for the treatment of major ailments, raising the potential for herb–drug interactions (HDIs). The major pathways postulated for HDIs involves the cytochrome P450 (CYP450)‐mediated inhibition or induction and transport and efflux proteins. In our review, we highlight frequently used herbal medicines for the treatment of cardiovascular disorders (CVD), their established HDIs studied using in vitro tools and in vivo pharmacokinetic and pharmacodynamic assays and case reports. Herbs have been divided into different sections on the basis of availability of HDI data in relevance to cardiovascular drugs: herbs reported to interact with cardiac drugs, herbs yet to be reported for interaction with drugs of any class and herbs reported to interact with drugs of other therapeutic category but not with cardiac drugs. The amount of active phytoconstituents present in the selected herbs and their extent of bioavailability are also mentioned. This review can serve as a quick reference database for physicians and health care professionals involved in CVD treatment, aimed at maximizing clinical outcomes with reduction in adverse and toxic effects.

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Section: Herbs Postulated To Induce Hdi With Cardiovascular Drugsmentioning

confidence: 99%

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Shaikh

Thomas

Chitlange

2020

Phytotherapy Research

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“…Terminalia chebula Retz. is widely used to treat dementia, constipation, and diabetes in traditional Indian and Iranian medicine ( Jokar et al., 2016 ). Studies showed that T. chebula Retz.…”

Section: Terminalia Sp Medicinal Potential (Folk Medicinal mentioning

confidence: 99%

“…Roxb., is widely used on treating diarrhea ( Pandey et al., 2017 ); Terminalia brownii Fresen., has been used to treat brown-erythematous excoriated papules and plaques ( Kibar Ozturk et al., 2018 ); T. chebula Retz. is widely used to treat dementia, constipation, and diabetes in traditional Indian and Iranian medicine ( Jokar et al., 2016 ), etc. Therefore, the active compounds existing in Terminalia sp.…”

Section: Introductionmentioning

confidence: 99%

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

et al. 2020

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The evaluation and confirmation of healing properties of several plant species of genus Terminalia based on their traditional uses and the clinical claims are of utmost importance. Genus Terminalia has received more attention to assess and validate the therapeutic potential and clinical approval due to its immense folk medicinal and traditional applications. Various species of Terminalia genus are used in the form of herbal medicine and formulations, in treatment of diseases, including headache, fever, pneumonia, flu, geriatric, cancer, to improve memory, abdominal and back pain, cough and cold, conjunctivitis, diarrhea, heart disorder, leprosy, sexually transmitted diseases, and urinary tract disorders. These are reported to possess numerous biological properties, counting: antibacterial, antifungal, antiinflammatory, antiviral, antiretroviral, antioxidant, and antipa7rasitic. This current research review aims to update the detailed biological activities, pre-clinical and clinical studies of various extracts and secondary metabolites from several plant species under the genus Terminalia , along with information on the traditional uses and chemical composition to develop a promising strategy for their potential applications in the form of medicine or use in modern drug formulations for treating diseases like pneumonia, flu, and other types of viral infections or controlling human contagions.

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“…Gandhrva hariaki is a potent laxative than Triphala churna. Roasted fruits treat diarrhea and soaked ones laxate (Iran) due to high tannins and anthraquinone derivatives, respectively 146 . Half-ripe purgate and the ripe is astringent in T. bellerica fruit 147 .…”

Section: Effect Of Geographical Variation On the Main Chemical Constimentioning

confidence: 99%

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2019

IJPSR

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Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine

Cited by 50 publications

References 20 publications

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

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