Potential therapeutic applications of the genus Annona : Local and traditional uses and pharmacology

Quilez, Ana Maria; Fernández-Arche, M.A.; García-Giménez, M.D.; Puerta, R. de la

doi:10.1016/j.jep.2018.06.014

Cited by 87 publications

(67 citation statements)

References 246 publications

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“…Nonetheless, Correa-Gordillo et al [53] came up with a review of the antioxidant capacity of Annona muricata and categorically stated that soursop did not contain high activity or concentration of antioxidants in leaves, fresh/frozen pulp, juice as well as wine from the plant. is review perfectly supports our nding in this study as regards the antioxidant feature of fruit-skin ethanol extract of Annona muricata [54,55].…”

Section: Discussionsupporting

confidence: 91%

Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract ofAnnona muricata

Iyanda-Joel

Ajetunmobi

Chinedu

et al. 2019

Journal of Toxicology

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Uncontrolled cell proliferation hallmarks cancer and most cancer cells have developed multiple resistance to the drugs employed for their treatment. The study examined the phytochemical and antioxidant properties of the fruit-skin ethanol extract of Annona muricata Linn. (ESA) and its effect on rat liver mitochondrial membrane permeability transition (MMPT). Qualitative phytochemical study and antioxidant assays were carried out following established protocols while the opening of the MMPT pore in the presence of varying concentrations of the extract was assayed spectrophotometrically under succinate-energized conditions. Calcium chloride (CaCl2) and spermine were used to trigger and inhibit pore opening respectively. Cytochrome c release was assayed for using ELISA kit. Terpenoids, steroids, phenols among other phytochemicals were found present in ESA and the extract showed very low antioxidant properties at the tested concentrations based on the diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity assay. Lipid peroxidation was induced in a concentration-dependent manner on both the cytosolic and mitochondrial hepatocyte fractions in vitro. In the absence of CaCl2 0.84 mg/mL concentration of ESA induced MMPT pore opening by 129% while the extracts showed no inhibitory activity in its presence. The induction fold corresponded with the concentrations of cytochrome c released. The fruit-skin ethanol extract of Annona muricata at certain concentrations may possibly contain bioactive compounds that induce apoptosis.

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Section: Discussionsupporting

confidence: 91%

Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract ofAnnona muricata

Iyanda-Joel

Ajetunmobi

Chinedu

et al. 2019

Journal of Toxicology

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“…The Annona species are moderately erect shrubs or small trees that grow to 5-11 m in height depending upon species and the region they inhabit, and are ferruginous to greyish, and tomentose when young, but later becoming glabrous [7]. Ethnobotanically, the plants from this genus play significant roles as food products and medicinal agents.…”

Section: Ethnomedicinal Uses Of Anonna Genusmentioning

confidence: 99%

“…In addition to the above antiprotozoal and antimicrobial activities, both the crude extracts from annona plants and the individual alkaloids have shown potent anticancer/antitumour activities.Many crude extracts of Annona species showed significant anti-cancer activities, but most of the bioactive constituents present in those crude extracts were acetogenins, fatty acids, and peptides [7]. However, wherever studied, it was known that some aporphine alkaloids, especially (−)-roemerine 49, which was isolated from the leaves of the wild custard apple, improved the response produced by vinblastine against multidrug-resistant KB-V1 or KB-3 cells (ED 50 > 20 µg/mL).…”

Section: Anticancer Alkaloids Present In the Genus Annonamentioning

confidence: 99%

Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities

et al. 2019

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Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for their anti-infective and anti-cancer activities. An isoquinoline backbone is a major structural alkaloid moiety of the Annona genus, and more than 83 alkaloids have been isolated from this genus alone. Crude extracts of Annona genus are reported with moderate activities against Plasmodium falciparum showing larvicidal activities. However, no pure compounds from the Annona genus were tested against the parasite. The methanol extract of Annona muricata showed apparent antimicrobial activities. The isolated alkaloids from this genus including liriodenine, anonaine, asimilobine showed sensitivity against Staphylococcus epidermidis. Other alkaloids such as (+)-Xylopine and isocoreximine indicated significant anti-cancer activity against A549 and K-562 cell lines, respectively. This review revealed that the alkaloids from Annona genus are rich in structural diversity and pharmacological activities. Further exploration of this genus and their alkaloids has potential for developing novel anti-infective and anticancer drugs.

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“…The genus Annona, which includes such species as A. muricata, A. squamosa, A. senegalensis and A. cherimoya, are known to have important pharmacological properties that treat many illnesses because it is rich in phenolic compounds [8]. Soursop (Annona muricata) or sirsak is a tropical plant species widely cultivated across Southeast Asia, including Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry and Antioxidant Activity of Soursop (Annona Muricata) Leaves

et al. 2019

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Objective: Soursop (Annona muricata) is a tropical plant which has been utilized as a folk medicine to treat many diseases including cancer, inflammation and parasitic infection. In this study, we investigated its phytochemistry properties and antioxidant activity against free radicals. Methods: Annona muricata leaves were extracted in three different solvents: ethanol, ethyl acetate and n-hexane. Afterwards, a phytochemistry test and the thin layer chromatography (TLC) method were used to evaluate bioactive compounds contained in the three different extracts. Antioxidant activity from the semi-polar (ethyl acetate) and polar (ethanol) solvents were evaluated by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and the antioxidant activity is expressed by IC50 value. The results were compared to ascorbic acid as a positive control. Results: The phytochemistry test showed that the extracts were positive for flavonoids, steroids, alkaloids, glycosides and tannins. Moreover, TLC analysis revealed that there were three chemical compounds contained in the extracts. The results from the DPPH method were that ethanolic extract was shown to have the most potent antioxidant activity with an IC50 value of 35.51 ppm. Conclusion: The ethanolic extract of Annona muricata could be developed as the next promising natural antioxidant source.

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Potential therapeutic applications of the genus Annona : Local and traditional uses and pharmacology

Cited by 87 publications

References 246 publications

Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract ofAnnona muricata

Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract ofAnnona muricata

Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities

Phytochemistry and Antioxidant Activity of Soursop (Annona Muricata) Leaves

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