Potential Therapeutic Targets of Quercetin and Its Derivatives: Its Role in the Therapy of Cognitive Impairment

Abstract

Quercetin (QC) is a flavonoid and crucial bioactive compound found in a variety of vegetables and fruits. In preclinical studies, QC has demonstrated broad activity against several diseases and disorders. According to recent investigations, QC is a potential therapeutic candidate for the treatment of nervous system illnesses because of its protective role against oxidative damage and neuroinflammation. QC acts on several molecular signals, including ion channels, neuroreceptors, and inflammatory receptor signaling, and it also regulates neurotrophic and anti-oxidative signaling molecules. While the study of QC in neurological disorders has focused on numerous target molecules, the role of QC on certain molecular targets such as G-protein coupled and nuclear receptors remains to be investigated. Our analysis presents several molecular targets of QC and its derivatives that demonstrate the pharmacological potential against cognitive impairment. Consequently, this article may guide future studies using QC and its analogs on specific signaling molecules. Finding new molecular targets of QC and its analogs may ultimately assist in the treatment of cognitive impairment.

The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial

“…Previous animal studies [ 36 , 46 ] highlighted that quercetin and Q3G significantly increased the mRNA expression and secretion of BDNF in rats, which contribute to the neural stem cell proliferation. The possible underlying mechanism could be the quercetin activates BDNF-TrkB and its associated signaling pathway, which eventually, results in phosphorylation of CREB, followed by an increase in extracellular signal-regulated kinase (ERK) and BDNF [ 47 , 48 ]. Therefore, quercetin interactions with these pathways may be responsible for its role in the central nervous system.…”

Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine

“…In addition, quercetin can reverse cognitive impairment and enhance memory in the ageing process. Quercetin has the protective effects of antioxidant damage and neuroinflammation, so it is a potential therapeutic candidate for the treatment of neurological diseases and is helpful for the treatment of cognitive impairment [ 126 , 127 ]. Multiple experiments have shown that quercetin has a neuroprotective effect [ 128 ].…”

G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits

“…These diseases lead to an irreversible weakening of all brain functions. Around 30 million individuals worldwide are affected by NDDs [3,4]. Alzheimer's disease (AD), vascular dementia (VaD), frontotemporal dementia Figure 1.…”