Potential Therapy for Rheumatoid Arthritis and Sjögren Syndrome With Human Chorionic Gonadotropin

Abstract

Autoimmune diseases such as rheumatoid arthritis (RA) and Sjögren syndrome (SS) ameliorate during pregnancy, through dampening (immunotolerance) of the maternal immune system which protects the fetus from rejection. A large number of studies have shown that human chorionic gonadotropin (hCG) contributes to this tolerance. Studies on animal models have reaffirmed that hCG treatment mimics the benefits of pregnancy. Based on the scientific evidence, randomized clinical trials comparing hCG with current therapies and/or placebo are recommended for RA, SS, and for other autoimmune diseases such as, type 1 diabetes and ankylosing spondylitis, which also get better during pregnancy and hCG treatment seems to help.

Inclusion of Human Chorionic Gonadotropin in the Family of Therapeutic Glycoproteins

“…18,19 IFN are a group of proteins that are made by virus (or other pathogens) infected cells in the body. 20,21 They belong to cytokine class family, which are communication molecules to trigger the protective defenses of the immune system. 20,21 There are 3 types; IFN-β belongs to type 1 and IFN-γ to type 11.…”

“…20,21 They belong to cytokine class family, which are communication molecules to trigger the protective defenses of the immune system. 20,21 There are 3 types; IFN-β belongs to type 1 and IFN-γ to type 11. 20,21 Among the IFNs, β and Υ are glycoproteins.…”

“…20,21 There are 3 types; IFN-β belongs to type 1 and IFN-γ to type 11. 20,21 Among the IFNs, β and Υ are glycoproteins. 20,21 They are antiviral molecules and can modulate the functions of immune system.…”

“…20,21 Among the IFNs, β and Υ are glycoproteins. 20,21 They are antiviral molecules and can modulate the functions of immune system. 20,21 They are used for the treatment of chronic granulomatous disease and multiple sclerosis.…”

“…20,21 They are used for the treatment of chronic granulomatous disease and multiple sclerosis. 20,21 mAbs are produced by hybridoma technology and contain 2 heavy and 2 light chains covalently bound by disulfide bridges.…”