2009 3rd International Conference on Bioinformatics and Biomedical Engineering 2009
DOI: 10.1109/icbbe.2009.5163209
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Potential Toxicity of Chronic Creatine Supplementation in Mice

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“…Subsequently, cytotoxic compounds are produced [ 21 , 68 ]. The accumulation of those compounds in mice was found as a result of high concentrations of methylamine and enhanced activity of SSAO [ 21 , 69 ]. Poortmans et al studied 21 g/day of creatine monohydrate oral supplementation in 20 healthy male individuals and revealed that high dose loading of creatine in a short period of time increased excreted levels of methylamine and formaldehyde, 9.2-fold and 4.5-fold in the urine, respectively.…”
Section: Role Of Semicarbazide-sensitive Amine Oxidase In Creatinementioning
confidence: 99%
“…Subsequently, cytotoxic compounds are produced [ 21 , 68 ]. The accumulation of those compounds in mice was found as a result of high concentrations of methylamine and enhanced activity of SSAO [ 21 , 69 ]. Poortmans et al studied 21 g/day of creatine monohydrate oral supplementation in 20 healthy male individuals and revealed that high dose loading of creatine in a short period of time increased excreted levels of methylamine and formaldehyde, 9.2-fold and 4.5-fold in the urine, respectively.…”
Section: Role Of Semicarbazide-sensitive Amine Oxidase In Creatinementioning
confidence: 99%