Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants

Faggio, Caterina; Morabito, Marina; Minicante, Simona Armeli; Piano, Giada Lo; Pagano, Maria; Genovese, Giuseppa

doi:10.1590/s1516-8913201500400

Cited by 46 publications

(21 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During the past decade extensive researches on diverse ranges of medical plants (whole plant, parts of plant or extract) and algal extracts revealed potentially beneficial effects of these feed additives on performance, immune response and disease resistance [32,34,35]. In this sense, the present study was performed to investigate antioxidant defence, immune response, growth and appetite of common carp following administration of Ferula powder in diet.…”

Section: Discussionmentioning

confidence: 99%

Transciptomic study of mucosal immune, antioxidant and growth related genes and non-specific immune response of common carp (Cyprinus carpio) fed dietary Ferula (Ferula assafoetida)

Safari

Hoseinifar

Nejadmoghadam

et al. 2016

Fish & Shellfish Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Transciptomic study of mucosal immune, antioxidant and growth related genes and non-specific immune response of common carp (Cyprinus carpio) fed dietary Ferula (Ferula assafoetida)

Safari

Hoseinifar

Nejadmoghadam

et al. 2016

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…). There is growing trend in the replacement of chemical drugs with herbal medicine and algal extracts, due to their potential health benefits with limited side effects (Peddie, Zou & Secombes ; Najafian & Babji ; Faggio, Morabito, Minicante, Piano, Pagano & Genovese ; Faggio, Pagano, Dottore, Genovese & Morabito ). Therefore, the study about immunostimulants, especially those of plant origin, which have antioxidant and immune property, has remarkably increased in recent years (Galina, Yin, Ardo & Jeney ).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary supplementation of palm fruit extracts on the transcriptomes of growth, antioxidant enzyme and immune-related genes in common carp (Cyprinus carpio ) fingerlings

et al. 2016

View full text Add to dashboard Cite

This study investigates the effects of date palm extracts [DPE] (Phoenix dactylifera L. Arecaceae) on growth, immune function and antioxidant system in common carp fingerlings (Cyprinus carpio). One hundred and twenty fish (4.06 ± 0.13 g) were divided into six groups fed on control diet or diets containing 200 mL kg−1 DPE for 8 weeks. At the end of feeding trial, the expression of different genes was measured. Selected genes were grouped into three categories: growth factor genes in brain and liver [growth hormone (GH), insulin‐like growth factors I and II (IGF‐I and IGF‐II), antioxidant‐related genes in liver [glutathione S‐transferase‐alpha (GST‐α), glutathione reductase (GR) and glutathione peroxidase genes (GPX)] and immune‐related genes in head kidney [interleukin‐8 (IL‐8), interleukin‐10 (IL‐10) and transforming growth factor‐beta (TGF‐β) genes]. The relative expression of the growth‐related genes in fish fed DPE showed no significant increase compared to control group (P > 0.05). On the other hand, DPE altered the expression of genes encoding antioxidants enzymes in liver of fingerlings which was statistically significant with respect to the control samples in case GPX (P < 0.05). Also, DPE caused remarkable increases in the expression of the immune‐related genes (IL‐8, IL‐10 and TGF‐β) analysed on head kidney of common carp fingerlings compared to the control group (P < 0.05). In conclusion, it can be suggested that administration of DPE in early stages of common carp culture can promote immune efficacy and increase the antioxidant activity.

show abstract

“…As already shown for algae polysaccharides, so do plant polysaccharides have anticoagulant activity [10–12], and can be used as a prevention and treatment of cardiovascular disease [13]. The aim of this study was to isolate, characterize and evaluate the anticoagulant and antithrombotic effects of the polysaccharides of blackberry seeds.…”

Section: Introductionmentioning

confidence: 95%

Antithrombotic mechanism of polysaccharides in Blackberry (Rubus spp.) seeds

Wang

Lian

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

The blackberry seed was typically removed as a byproduct and waste from blackberry fruits for juices. Developing value-added utilization of berry seeds will significantly expand the market for berry products as well as improve benefit to berry producers. However, the research on blackberry seed is limited. The objective of this paper was to research antithrombotic mechanism of polysaccharides in blackberry seeds. Polysaccharides in blackberry seeds were extracted, purified and identified by high-performance gel permeation chromatography (HPSEC), gas chromatography (GC), fourier transform infrared (FT-IR) spectrometer and nuclear magnetic resonance spectra (NMR). Anticoagulant activities were evaluated in vivo by measuring activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), fibrinogen (FIB) and plasma recalcification time (RRT). Four polysaccharides named BSP-1a, BSP-1b, BSP-2 and BSP-3 were isolated from Blackberry (Rubus spp.) seeds. The results indicated that BSP-1b, BSP-2 and BSP-3 exhibited the anticoagulant activity. Therefore, the anti-thrombosis effects of BSP-1b, BSP-2 and BSP-3 were investigated in vivo by 6-Keto-PGF1α, thromboxane B2 (TXB2), endothelial nitric oxide synthase (eNOS), endothelin-1 (ET-1), whole blood viscosity (WBV), plasma viscosity (PV), hematocrit (Hct), erythrocyte sedimentation rate (ESR), APTT, TT, PT and FIB. The results suggested that BSP-1b, BSP-2 and BSP-3 had the inhibition effect on thrombus formation, and the antithrombotic effects were associated with the regulation of vascular endothelium active substance, activating blood flow and anticoagulation effect.

show abstract

Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants

Abstract: ABSTRACT

Cited by 46 publications

References 48 publications

Transciptomic study of mucosal immune, antioxidant and growth related genes and non-specific immune response of common carp (Cyprinus carpio) fed dietary Ferula (Ferula assafoetida)

Transciptomic study of mucosal immune, antioxidant and growth related genes and non-specific immune response of common carp (Cyprinus carpio) fed dietary Ferula (Ferula assafoetida)

Effect of dietary supplementation of palm fruit extracts on the transcriptomes of growth, antioxidant enzyme and immune-related genes in common carp (Cyprinus carpio ) fingerlings

Antithrombotic mechanism of polysaccharides in Blackberry (Rubus spp.) seeds

Contact Info

Product

Resources

About