Potential Value of Plants As Sources of New Antifertility Agents I *

Farnsworth, N. R.

doi:10.1002/jps.2600640404

Cited by 209 publications

(88 citation statements)

References 272 publications

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“…The less efficient ananai concentration was 0.15 g/ml, which presumed that lower concentration did not induce abortifacient effects: LASZLO & HENSHAW (1954) cited the presence of a substance in un ripe Ananas comosus and Ananas sativus juices, that oMnking fresh or tak-(PATON, 1968; EARNS WORTH et al, ing raw, would interfere on the implan-1975). Those substances could have estation or in development of the pregnancy trogenic activity (FEURT & FOX, 1955) and/or stimulate uterine tissue either in vitro or in vivo, through the amine, 5-hydroxytryptamine (FARNSWORTH et al, 1975) and/or having an ecbolic ac tivity through the bromelain, proteolytic enzyme from the pineapple plant (NAKAMSHI & AOYAMA, 1980).…”

Section: Resultsmentioning

confidence: 99%

“…(Ananai) in the suspension form of tea, is generally recognized in the Amazon region of Brazil as having an abortive effect in women if used until the 12th week of gestation. Furthermore, other species of Bromeliacea are currently considered as antifertility agents FARNSWORTH et al (1975). It is well reported in humans and animals that the time during which each organ system in the body is being established, when obligatory inductive tissue interactions and morphogenesis are occurring, is called the critical period for that structures during the first few days of the development (WILMUT et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

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ABORTIFACIENT EFFECTS OF Ananas ananassoides BAK. (Ananai) IN RATS

et al. 1993

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-The tea made from the infrutescense (corresponding to the edible part plus its cover) of ananai (Ananas ananassoides BAK.) was administered to pregnant rats, during the period of embryos implantation (5th -6th day through pregnancy). The animals were slaughtered on the 14th -15th day through the pregnancy and average rates of implantation and resorption were stimated.The results showed that this plant has an effective abortifacient effect, showing a strong inhibitory action on the implantation and/or post-implantation as well as a teratogenic effect, being more efficient in the concentration of 0,60 g/ml (P< 0.001).Key words: abortifacient, reproduction control, ananai, rats. Efeitos abortivos de Ananas ananassoides BAK. (Ananai) em ratos. RESUMO -O chá da infrutescência (frutículo mais a casca) do ananai (Ananas ananassoides)foi administrado em ratas grávidas, no período de implantação dos embriões (5 o -6 o dia de gestação). Os animais foram sacrificados no 14° -15° dia de gestação e a média de implantes e reabsorções foi avaliada. Verificou-se que esta planta tem efeito abortivo, produzindo importante efeito inibitòrio na implantação e/ou pós-implantação e efeito teratogênico, principalmente a partir da concentração 0,60 g/ml (P< 0.001).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ABORTIFACIENT EFFECTS OF Ananas ananassoides BAK. (Ananai) IN RATS

et al. 1993

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“…57 Farnsworth et al have written on the use of plants as abortifacients. 58 Of the 565 species listed as having a reputation in folklore of being abortifacients, only 12 had, up to the time of publication of this review article, been shown to cause abortions in human beings; 59 at least one (quinine) was unknown to Europe in the Roman period. 60 Furthermore there is reason to doubt the ability of people in the ancient Mediterranean world to identify plants, even when lives depended on correct identification.…”

Section: Ancient Methods Of Abortionmentioning

confidence: 98%

Malaria and Miscarriage in Ancient Rome

Stivala

2015

Canadian Bulletin of Medical History

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Abstract. Many Roman authors have claimed that induced abortions were frequent among aristocratic women in their society. They assumed that abortion was a simple procedure, easy to perform, and generally harmless for the women involved. The truth of these claims is frequently accepted by modern scholars. This article will argue that most supposed "abortions" were miscarriages caused by various infectious diseases, especially malaria. Keywords. Rome, abortion, malaria, miscarriageRésumé. Beaucoup d'auteurs romains ont affirmé que les avortements provoqués étaient fréquents parmi les femmes aristocratiques de leur société. Ils supposaient que l'avortement était une simple procédure, facile à réaliser, et géné-ralement inoffensive pour les femmes impliquées. La vérité de ces affirmations est généralement acceptée par les spécialistes modernes. Cet article soutiendra que la plupart des supposés « avortements » étaient des fausses-couches causées par diverses maladies infectieuses, particulièrement la malaria.

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“…São também atribuídos a berberina, ações antisséptica e ocitócica (Cunha et. al., 2003) e uma atividade uterina (Farnsworth, 1975), antiinfl amatória (Barbosa-Filho et al, 2006a) e inibidor da enzima acetilcolinesterase (Barbosa-Filho et al, 2006b). Possui ação antimicrobiana (Pizzorno;Murray, 1985).…”

Section: A Robusterinaunclassified

Desenvolvimento e validação de metodologia para quantificação de alcalóides totais como berberina em fitoterápico contendo Berberis vulgaris L.

Oliveira¹,

Albuquerque²,

Xavier³

et al. 2006

Rev. bras. farmacogn.

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Unitermos: Robusterina® , fi toterápico, validação, alcalóides, doseamento.ABSTRACT: "Development and validation of a method for the quantifi cation of total alkaloids as berberine in an herbal medicine containing Berberis vulgaris L.". Robusterina ® is a herbal medicine, with effectiveness in the treatment of menstrual cycle disfunctions. Its composition includes Berberis vulgaris L., with sedative and antispasmodic action; Gossypium herbaceum L., with emmenagogue, hemostatic and ocitocic action; Viburnum opulus L., with antispasmodic action for the treatment of menstrual colics. In accordance with Resolution RDC N° 48, of 16 of March of 2004 (ANVISA, Brazil) the product meets the defi nition of "Fitoterápico" (phytotherapeutic agent). The presence of alkaloids in Berberis vulgaris and the absence of analytical methodologies for quantifi cation of the product, stimulated us to develop and validate a method in accordance with Resolution RE N° 899, of 29 of May of 2003. Such methodology is based on the determination of alkaloids using a spectrophotometric method, with Dragendorff as a precipitating reagent, and using berberine sulphate, as a standard. The calibration curve was determined with six concentrations ranging between 40 and 200 μg/mL. The equation of the calibration curve is y = 0.0038x + 0.0092 with R 2 of 0.9996. The parameters robustness, precision, specifi city, limit of detection and quantifi cation and accuracy have been evaluated using 95% confi dence interval (test t of Student, ANOVA). Keywords: Robusterina® , herbal medicine, validation, alkaloids, quantifi cation. INTRODUÇÃOA Robusterina ® é um medicamento (solução oral) de origem exclusivamente vegetal. Encontra-se no mercado nacional desde 1932, sendo utilizada no tratamento das disfunções e regulação do ciclo menstrual e, por estimular a contração uterina, seu uso é contraindicado no período gestacional. A dose média diária é de uma colher de sopa (15 mL) 3 vezes ao dia. O tratamento deve ser suspenso quando houver normalização do ciclo menstrual, ou no caso de gravidez. Apresenta-se em sua constituição três plantas: Berberis vulgaris, Gossypium herbaceum e Viburnum opulus.Para o estudo, foi dada ênfase a Berberis vulgaris, pois é a única planta que apresenta na sua constituição alcalóides, para a qual foi desenvolvida 358 Desenvolvimento e validação de metodologia para quantifi cação de alcalóides totais como berberina em fi toterápico contendo Berberis vulgaris L.

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Potential Value of Plants As Sources of New Antifertility Agents I *

Cited by 209 publications

References 272 publications

ABORTIFACIENT EFFECTS OF Ananas ananassoides BAK. (Ananai) IN RATS

ABORTIFACIENT EFFECTS OF Ananas ananassoides BAK. (Ananai) IN RATS

Malaria and Miscarriage in Ancient Rome

Desenvolvimento e validação de metodologia para quantificação de alcalóides totais como berberina em fitoterápico contendo Berberis vulgaris L.

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