Potentially-implantable, ferrocene-mediated glucose sensor

Claremont, D. J.; Penton, C; Pickup, John C.

doi:10.1016/0141-5425(86)90095-6

Cited by 41 publications

(15 citation statements)

References 5 publications

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“…Firstly, the electrodes were calibrated in buffered glucose solutions and it is not known how interstitial fluid alters this calibration. It is of note here that, in a previous study [9], we reported that albumin at a concentration of 80 g/1 did not alter electrode responses and that plasma glucose levels at and below euglycaemia were similar, when measured by the ferrocene glucose sensor and a standard laboratory method.…”

Section: Discussionmentioning

confidence: 88%

“…The postulated mechanism of direct transfer of electrons via ferrocene is supported by our demonstration of a 98% reduction in current output when electrodes were constructed without the addition of ferrocene. The participation of hydrogen peroxide in the functioning of the sensor is also made unlikely by the previously reported oxygen insensitivity of the electrode [8,9] and its low operating voltage of 160mV (cf 600 mV for H202-detecting sensors [6]). …”

Section: Discussionmentioning

confidence: 99%

“…There is experimental evidence, however, that variations in oxygen are not major modulators of the output of the present glucose sensor [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…The construction of glucose sensors has been described previously [9]. In brief, 1 mm wide graphite foil strips (Papyex, Le Carbone, Portslade, Sussex, UK) acted as the base electrode.…”

Section: Methodsmentioning

confidence: 99%

“…We recently described [9] the construction and in vitro characteristics of a miniature, dimethylferrocenebased glucose sensor. We now report studies in which the sensor was implanted in the subcutaneous tissue of non-diabetic pigs (a species where this tissue is similar to that of man), and responses were compared to conventionally measured blood glucose concentrations.…”

mentioning

confidence: 99%

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Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs

et al. 1986

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Summary. Miniature, amperometric glucose sensors were constructed using entrapped 1,1'-dimethylferrocene to mediate electron transfer between immobilised glucose oxidase and a carbon base electrode. Electrodes were calibrated in buffered glucose solutions and then implanted in the subcutaneous tissue of anaesthetised, non-diabetic pigs. Subcutaneous tissue glucose concentrations, as measured by the sensor, were about 20% of blood glucose values, measured by a conventional glucose oxidase assay. After an intravenous 0.07 mol bolus glucose injection, electrode responses increased with almost no time lag, but the subsequent rates of rise and fall of electrodemeasured tissue glucose concentrations were slower than that of the blood values. After an intravenous 0.2 U/Kg bolus short-acting insulin injection the electrode response was also rapid, but decreased at a slower rate than the blood glucose concentrations. We conclude that this is a feasible technology for future development as an implantable glucose sensor for use in diabetic man.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

“…There is experimental evidence, however, that variations in oxygen are not major modulators of the output of the present glucose sensor [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…The construction of glucose sensors has been described previously [9]. In brief, 1 mm wide graphite foil strips (Papyex, Le Carbone, Portslade, Sussex, UK) acted as the base electrode.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs

et al. 1986

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Mediated electron transfer from glucose oxidase at a ferrocene‐modified graphite electrode

1989

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A new ferrocene derivative was synthesized by reacting hydroxymethylferrocene with anthracene-9carboxylic acid. This new compound strongly adsorbs on the surface of a graphite electrode to form a stable chemically modified electrode. The formal potential of the adsorbed ferrocene derivative was +340 mV versus SCE in solutions containing 0.1 M perchlorate. When adsorbed, the ferrocene derivative mediates the charge transfer between the electrode and glucose oxidase.

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Nickelocene‐mediated glucose oxidase electrode

et al. 1993

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Nickelocene is investigated as an electrochemical mediator in glucose oxidase (GOD) amperometric electrodes. It is found that the adsorbed nickelocene mediates the charge transfer between the electrode and glucose oxidase adsorbed on the electrode surface. The quasi redox potential of a nickelocene/nickelocenium couple adsorbed on an electrochemically activated pyrolytic graphite electrode is experimentally estimated ( -0.105 V vs. Ag/AgCl). The steady-state amperometric response of nickelocene-mediated glucose electrode is investigated as a function of the glucose concentration, applied potential, and solution pH of the electrolyte. The working potential of a nickelocene-mediated glucose electrode is 0.00 V (vs. Ag/AgCl).

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Potentially-implantable, ferrocene-mediated glucose sensor

Cited by 41 publications

References 5 publications

Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs

Subcutaneous implantation of a ferrocene-mediated glucose sensor in pigs

Mediated electron transfer from glucose oxidase at a ferrocene‐modified graphite electrode

Nickelocene‐mediated glucose oxidase electrode

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