Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate

Abstract

Five solid membrane sensors responsive to memantine hydrochloride (MEM) and pramipexole dihydrochloride monohydrate (PXL) are described for simple and fast determination of these drugs in pharmaceutical preparation and human plasma. The first and the second sensors are based on the formation of an ion association complex between MEM as a cationic drug with Na tetra phenyl borate and ammonium reineckate (as anionic exchanger), respectively. The third sensor is based on the formation of an ion association complex between PXL with ammonium reineckate. The produced electroactive material is dispersed in PVC matrix. While the other fourth and fifth sensors are based on using functionalized lipophilic cyclodextrin derivative (2-hydroxypropyl-β-cyclodextrin) as sensor ionophore for the determination of MEM and PXL. The performance characteristics of these sensors-evaluated according to IUPAC recommendations-reveal fast, stable and near Nernstian response for 1x10-4-1x10-1 M and 1x10-6-1x10-2 M for (MEM) and (PXL), respectively. Many inorganic and organic substances such as drug excipients and diluents normally used in drug formulations do not interfere with drugs response. Statistical comparison between the results obtained by applying the proposed potentiometric method for the determination of the (MEM) and (PXL) in their pure powder forms and those obtained by applying the reported methods was done and no significant difference was found at p = 0.05. Validation of the method according to ICH guidelines shows the suitability of the sensors for quality control analysis of the cited drugs in pharmaceutical formulations and human plasma. The proposed sensors can also be used as a detector for HPLC.

Spectrophotometric Methods for the Quantitative Determination of Memantine Hydrochloride in Pure Form and Pharmaceutical Formulations

“…Memantine also has antagonistic activity at the type 3 serotonergic (5-HT3) receptor with a potency that is like that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor [1,2]. Several methods for analysing MEM in pure drugs, pharmaceutical dosage forms, and biological samples have been described in the literature, including high performance liquid chromatography [3][4][5], liquid chromatography coupled with fluorescence detection [5][6][7][8][9] and mass spectrometry [10][11][12][13], gas chromatography with mass spectrometry (GC-MS) [14], potentiometry [15,16], and spectrofluorimetric [17,18]. These procedures, on the other hand, are costly, difficult to use for routine analysis, time consuming, and not available in most laboratories.…”

3D spongy-like Au film for highly stable solid contact potentiometric ion selective electrode: application to drug analysis

“…A simple solution that can meet these requirements is to use ion selective electrodes. Indeed, several conventional PVC membrane ion selective electrodes with different types of ion exchangers were proposed for determination of memantine in pharmaceutical formulation [16][17][18]. Although the proposed electrodes exhibited a wide linear range with satisfactory sensitivity and selectivity, the liquid contact electrode requires special skills for preparation and handling which limits its application for quality control and on-line process analysis.…”

Bridging Pharma and Sustainability: Green Electrochemical Analysis of Antiparkinsonian Drug in Pharmaceuticals and Plasma, Aligned with United Nations Goals via the NQS Index

“…6,7 Various analytical methods have been used for measurement PRA in its tablets and/or plasma, including high-performance liquid chromatography, HPLC, [8][9][10][11][12][13][14][15] high-performance thin layer chromatography, HPTLC, 16 liquid chromatography-tandem mass spectrometry, LC-MS/MS, 17,18 gas chromatography-mass spectrometry GC/MS, 19 spectrophotometry, 16,[20][21][22][23][24] and potentiometry. 25,26 Electrochemical methods offer a highly favorable analytical approach, distinguished by a variety of eco-friendly attributes. One prominent characteristic lies in the utilization of aqueous media, which facilitates ease of operation and reduces environmental impact compared to other solvents.…”