Potentiometric Titration in Pharmaceutical Control

Potentiometric Titrations

“…West (173) has reviewed the topic of titrations in anhydrous solvents. Waters, Berg, and Lachman (172) have surveyed the scope of potentiometric titrations in pharmaceutical control.…”

Pharmaceuticals and Natural Drugs

“…A new approach to the analysis of cinchona and nux vomica (288) is described, in which the alkaloids are separated from the plant constituents by microsublimation from the powdered drug which has been treated with sodium carbonate. The determination of barbiturates, their sodium salts, and other organic salts by titration procedures in which potentiometric means of determining the various end points are utilized is discussed by Waters et al (271). These procedures are reported to be of particular value in colored solutions where the use of indicators would be limited.…”

Evaluation of Amperometric and Potentiometric Titrations of Phenobarbital Elixir with Mercury (II)

“…Phenobarbital has been successfully titrated in both aqueous and nonaqueous media with a variety of bases (4-1 1). This technique could not be applied to phenobarbital in elixir dosage forms (10). Mattocks and Voshall (l), and more recently Bodin (12), titrated phenobarbital elixir potentiometrically with silver nitrate to a predetermined potential.…”