Pouch adenocarcinoma after restorative proctocolectomy for familial adenomatous polyposis

Cherki, Stéphane; Gléhen, Olivier; Moutardier, Vincent; François, Y.; Gilly, F. N.; Vignal, J

doi:10.1046/j.1463-1318.2003.00486.x

Cited by 31 publications

(16 citation statements)

References 21 publications

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“…There are several reported cases of adenocarcinomas arising in an ileal pouch after RPC for CUC [10][11][12][13][14][15][16][17][18][19] and FAP 20-24 of patients who had mucosectomies 10,[12][13][14][15]17,18,[20][21][22] and double-stapled anastomoses. 19,[22][23][24] However, it is not clear that these cancers are in fact true de novo small-bowel malignancies.…”

Section: Discussionmentioning

confidence: 99%

Mucosal Dysplasia in Ileal Pelvic Pouches After Restorative Proctocolectomy

Nilubol¹,

Scherl²,

Bub³

et al. 2007

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Mucosal Dysplasia in Ileal Pelvic Pouches After Restorative Proctocolectomy

Nilubol¹,

Scherl²,

Bub³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…This is in fact suggested by the description by Beveridge et al [214] of two large villous adenomas in a pouch displaying all the risk factors of malignant transformation: size, sessile nature, severity of dysplasia and villous architecture. Three cases of true pouch adenocarcinomas have in fact been reported after IPAA [213,223,224]. All reported cases of pouch cancer in FAP had a high cancer risk at the time of IPAA [39].…”

Section: Risk Of Neoplasia In the Ileal Pouchmentioning

confidence: 99%

Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited

et al. 2006

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Since restorative proctocolectomy (RPC) with ileal-pouch anal anastomosis (IPAA) removes the entire diseased mucosa, it has become firmly established as the standard operative procedure of choice for familial adenomatous polyposis (FAP). Many technical controversies still persist, such as mesenteric lengthening techniques, close rectal wall proctectomy, endoanal mucosectomy vs. double stapled anastomosis, loop ileostomy omission and a laparoscopic approach. Despite the complexity of the operation, IPAA is safe (mortality: 0.5-1%), it carries an acceptable risk of non-life-threatening complications (10-25%), and it achieves good long-term functional outcome with excellent patient satisfaction (over 95%). In contrast to the high incidence in patients operated for ulcerative colitis (UC) (15-20%), the occurrence of pouchitis after IPAA seems to be rare in FAP patients (0-11%). Even after IPAA, FAP patients are still at risk of developing adenomas (and occasional adenocarcinomas), either in the anal canal (10-31%) or in the ileal pouch itself (8-62%), thus requiring lifelong endoscopic monitoring. IPAA operation does not jeopardise pregnancy and childbirth, but it does impair female fecundity and has a low risk of impairment of erection and ejaculation in young males. The latter can almost completely be avoided by a careful "close rectal wall" proctectomy technique. Some argue that low risk patients (e.g. <5 rectal polyps) can be identified where ileorectal anastomosis (IRA) might be reasonable. We feel that the risk of rectal cancer after IRA means that IPAA should be recommended for the vast majority of FAP patients. We accept that in some very selected cases, based on clinical and genetics data (and perhaps influenced by patient choice regarding female fecundity), a stepwise surgical strategy with a primary IPA followed at a later age by a secondary proctectomy with IPAA could be proposed.

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“…[7][8][9][10][11][12][13] In addition, there were five reports of cancers arising from the ileal pouch mucosa, as opposed to from the anastomosis, in patients with FAP. [14][15][16][17][18] In our center, patients with FAP underwent Kock pouch construction or an IRA until 1987. However, since the introduction of IPAA in our center in 1988, we have favored IPAA as the operation of first choice for the treatment of patients with FAP.…”

Section: Introductionmentioning

confidence: 99%