Pouteria campechiana leaf extract and its bioactive compound myricitrin are mosquitocidal against Aedes aegypti and Culex quinquefasciatus

Sangeetha, R.; Pratheeba, Tamilselvan; Ragavendran, Chinnasamy

doi:10.4103/1995-7645.262076

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…This study investigated the chemical constituents of 70% MeOH extract of the whole plants of P. aviculare yielded six flavonoid glycosides: avicularin (1) [15], juglanin (2) [16,17], myricitrin (3) [18], agetiin (6) [19,20], miquelianin (7) [21], and astragalin (8) [22]; Aviculin (4), one lignan [23] and 6-di-O-galloyl-β-D-glucopyranose (5), one galloyl glycoside [24]. Their chemical structures are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of DNA Topoisomerases I and II and Cytotoxicity of Compounds from Polygonum aviculare L .

Zheng

Piao

et al. 2021

Preprint

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Six flavonoid glycosides ( 1 – 3 , 6 – 8 ), one lignan ( 4 ), and one galloyl glycoside ( 5 ) were isolated based on the phytochemical study for the MeOH extract of Polygonum aviculare L. herb. The eight isolated compounds' structures were determined by comparing their physicochemical and spectral data with published ones. Compounds 5 and 6 were first isolated from this plant, and all the compounds were evaluated for DNA topoisomerase inhibitory activities and cytotoxicities. Among the purified compounds, 5 showed stronger inhibitory activity against topoisomerase I with an IC 50 value of 12.0 μM, while the value of positive control camptothecin (CPT) was 17.0 μM. For compounds 1 , 3 , and 5 – 8 , the value ranged from 0.054 to 17.0 µM, suggesting more potent inhibitory activity against topoisomerase II, and that of etoposide (VP-16) was 28.0 µM. Particularly, compounds 6 and 8 (IC 50 = 0.054 and 0.077 µM, respectively) inhibited Topo II about 500 times stronger than VP-16, making them safer agents of DNA topoisomerase. Furthermore, all compounds demonstrated no cytotoxic activity against four cancer cell lines. This study is the first to report the inhibition of DNA topoisomerases of compounds from P. aviculare , suggesting that these compounds may be potential candidates for treating cancer.

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Section: Resultsmentioning

confidence: 99%

Inhibition of DNA Topoisomerases I and II and Cytotoxicity of Compounds from Polygonum aviculare L .

Zheng

Piao

et al. 2021

Preprint

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A systematic review on phytochemicals for the treatment of dengue

Ali¹,

Chorsiya

Anjum

et al. 2020

Phytotherapy Research

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Dengue fever is prevalent in subtopic regions, producing mortality and morbidity worldwide, which have been of major concern to different governments and World Health Organization. The search of new anti‐dengue agents from phytochemicals was assumed to be highly emergent in past. The phytochemicals have been used in wide distribution of vector ailments such as malaria. The demand of the phytochemicals is based on the medicines which are mostly considered to be safer, less harmful than synthetic drugs and nontoxic. This review mentions majorly about the phytochemicals potentially inhibiting dengue fever around the world. The phytochemicals have been isolated from different species, have potential for the treatment of dengue. Different crude extracts and essential oils obtained from different species showed a broad activity against different phytochemicals. The current studies showed that natural products represent a rich source of medicines toward the dengue fever. Furthermore, ethnobotanical surveys and laboratory investigation established identified natural plants species in the development of drug discovery to control the dengue fever.

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Myricitrin: Resources, Bioavailability, Bioactivity, and Potential Applications

Geng,

Xie,

et al. 2023

Handbook of Dietary Flavonoids

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Pouteria campechiana leaf extract and its bioactive compound myricitrin are mosquitocidal against Aedes aegypti and Culex quinquefasciatus

Cited by 6 publications

References 4 publications

Inhibition of DNA Topoisomerases I and II and Cytotoxicity of Compounds from Polygonum aviculare L .

Inhibition of DNA Topoisomerases I and II and Cytotoxicity of Compounds from Polygonum aviculare L .

A systematic review on phytochemicals for the treatment of dengue

Myricitrin: Resources, Bioavailability, Bioactivity, and Potential Applications

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