Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

Saker, A.; Cares-Pacheco, Maria Graciela; Marchal, Philippe; Falk, Véronique

doi:10.1016/j.powtec.2019.05.032

Cited by 63 publications

(34 citation statements)

References 18 publications

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“…The results confirm that all selected parameters (e.g., flow properties) were in the satisfactory range [ 37 , 38 ]. The flow properties of the blend were confirmed by the Hausner ratio and are shown in Table 10 .…”

Section: Resultssupporting

confidence: 65%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk assessment methodology. A fractional factorial design was used by selecting five independent variables viz., chitosan concentration, tripolyphosphate concentration, and acetic acid concentration as material attributes, stirring speed, and stirring time as process parameters, whereby their influence on two dependent variables such as particle size (PS) and %entrapment efficiency (%EE) was studied. MetNp were synthesized by employing an ionic-gelation technique and optimized formula obtained from the QbD design study. PS and %EE studies revealed the formation of MetNp with 558.06 ± 2.52 nm and 59.07 ± 2.15%, respectively. Furthermore, a Met release study in various simulated gastro-intestinal media suggested pH-triggered (pH > 7.0) and sustained release profile of Met from Eudragit S100 enteric-coated MetNp capsule (MetNp cap). Moreover, the stability investigation of formulations confirmed good stability with respect to their PS and residual drug content (RDC) at different temperature conditions. In conclusion, the QbD method was effectively utilized in the development of MetNp and enteric-coated MetNp cap depicting their potential to release Met through MetNp cap only in the colon region and can be utilized for the treatment of amoebiasis in the colon.

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Section: Resultssupporting

confidence: 65%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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“…The fixed cylinder was dropped from a high of 2.5 cm at one-second intervals. 28 The tapping was continued until no further change in volume was noted. The tapped volume (Vt) was measured cm 3 .…”

Section: Density Measurementsmentioning

confidence: 99%

An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design

Mady¹,

Al-Shoubki²,

Donia³

2021

DDDT

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“…The asymptotic volume fraction is representative of maximal packing fraction achieved by tapping the powders. With this parameter, one obtains the final packing fraction η ∞ consequently the more common parameter, Hausner ratio Hr ¼ η 500 η 0 [6,40,41]. The Hausner ratio is correlated to the powder flowability whereby high value of Hr corresponds to low flowability.…”

Section: Granupackmentioning

confidence: 99%

Powder flow behavior governed by the surface properties of glass beads

et al. 2021

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Powder rheology and its sensitivity to surrounding environmental condition by controlling the surface properties of the particles is one of the major challenges of the powder industries. Indeed, handling large quantities needs powders with good flowability, adequate compressibility and few electrostatic charges. We have performed a chemical treatment in order to obtain hydrophobic glass beads and its bulk behavior has been compared with raw glass beads depending on the humidity. We characterized flow properties under different processing equipments. We observed that by performing hydrophobic surface treatment sensitivity of glass beads reduced to the humidity. Furthermore, the influence of the electrostatic charges was an undeniable factor in increasing the viscosity of hydrophobic glass beads and consequently lowering its flowability in front of raw glass beads; at low shear rate. At high shear rate, the powders presented similar behaviors.

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Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

Cited by 63 publications

References 18 publications

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design

Powder flow behavior governed by the surface properties of glass beads

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