2021
DOI: 10.48550/arxiv.2108.11466
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Power considerations for generalized estimating equations analyses of four-level cluster randomized trials

Abstract: In this article, we develop methods for sample size and power calculations in four-level intervention studies when intervention assignment is carried out at any level, with a particular focus on cluster randomized trials (CRTs). CRTs involving four levels are becoming popular in health care research, where the effects are measured, for example, from evaluations (level 1) within participants (level 2) in divisions (level 3) that are nested in clusters (level 4). In such multi-level CRTs, we consider three types… Show more

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