This paper presents cemented carbide layer thickness optimization of a carbide anvil based on thermodynamic coupling analysis. In our method, the established carbide anvil system through SolidWorks is firstly imported into the finite element software. The temperature field and thermal-mechanical coupling field of the carbide anvil system are analyzed. From the simulation results, it can be found that the contact stress of steel ring under temperature load is increased by 17.9% compared with that without temperature load. Thus, the service life of carbide anvil under temperature load is lower than that without temperature load. In addition, the four edges of anvil are prone to fatigue cracks due to the phenomenon of shear stress concentration. This is consistent with the actual crack location of cemented carbide anvil, which verifies the accuracy and rationality of thermal-mechanical coupling simulation. The thickness of cemented carbide layer is optimized based on thermodynamic coupling. The optimization results show that the thickness of 1.8cm is the best when size ranges from 1.8cm to 2.2cm. The maximum contact stress, the maximum shear stress, the temperature are all reduced by 387.5MPa, 110.55MPa, and 10.11℃, respectively.