Pp-119 Radioisotope Synovectomy Results in Ege Adult Hemophilia Center (2001–2011): 11 Years Experience

Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review

“…Forty‐three studies had sample sizes > 20 knees 5–47 . Sixty‐eight studies were defined as small and were not discussed further.…”

“…23 Y-90 cohorts with follow up durations up to 11 years have identified no incident cancer. 28,30,43 Additionally, no cancer cases were identified following P-32 RSV with a maximum follow up of 17 years in a small number of patients. 13,36 A large study using Canadian registry data of cancer rates following RSV in multiple joints (69% knees), found no significant increase in the hazards ratio of any type of cancer compared to the general population for either Y-90 or P-32.…”

“…The risk of complications of knee RSV is low many cohorts reporting no complication with Y-90 or P32. 11,18,24,29,30,43,45 Local complications consist of bleeding and infection as well as radiation induced acute synovitis, skin burns and tract necrosis.…”

“…35 The rates of PWH requiring a second Y-90 RSV range widely from 4−34%. 24,30,32,33,35,42,47 Eight to 30% require a third RSV. 30,35 Repeat injections continue to be effective across several parameters, however the efficacy is reduced.…”

“…24,30,32,33,35,42,47 Eight to 30% require a third RSV. 30,35 Repeat injections continue to be effective across several parameters, however the efficacy is reduced. 34 A weak correlation has been identified between thicker synovium and the need to administer repeat RSV injections suggesting it may take more procedures to achieve adequate bleeding control in those with worse baseline synovitis.…”