Recently, due to the promising application of metal oxide semiconductors in high-performance methane (CH 4 ) sensors, more attention has been paid to the development of feasible strategies for improving CH 4 sensing performance. Herein, we present a strategy of cadmium (Cd) doping to improve the CH 4 sensing property of In 2 O 3 porous hollow nanospheres (PHNSs). The Cd-doped In 2 O 3 PHNSs were prepared via an impregnation−calcination approach with self-made carbon nanospheres as a hard template. The samples were characterized by various techniques to evaluate their structure, morphology, surface state, composition, and band gap. When applied as a sensitive material in the CH 4 sensor, the Cd-doped In 2 O 3 PHNSs, compared with bare In 2 O 3 PHNSs, showed some significant improvements in performance, especially a reduced operating temperature (200 °C vs 300 °C), an enhanced response (9.5 vs 2.5 for 500 ppm of CH 4 ), a faster response speed (16 s vs 276 s), and better selectivity. In addition, the Cd-doped In 2 O 3 sensor can also maintain a commendable long-term stability, and the range of its response amplitude within 30 days is only 6.3%. The sensitization effects of the Cd dopant on the In 2 O 3 PHNSs are discussed.