2021
DOI: 10.21203/rs.3.rs-962678/v1
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PPP2R5D Promotes Hepatitis C Virus Infection Through Binding to NS5B Protein

Abstract: Background: Hepatitis C virus (HCV) is an important human pathogen causing chronic hepatitis C, end-stage liver diseases, and hepatocellular carcinoma. The development of infectious HCV cell culture systems primarily relied on the replication enhancement effect of adaptive mutations. Although the mode of action may vary, those adaptive mutations could direct the study of virus-host interactions required for efficient virus infection. We previously identified a substitution D559G in NS5B (RNA dependent RNA poly… Show more

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