Practical Approach to the Investigation of Neutropenia

Foucar, Kathy; Duncan, Mark; Smith, Kenneth J.

doi:10.1016/s0272-2712(18)30414-1

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…Das Knochenmark eines gesunden Menschen produziert täglich etwa 1 -2x10 9 /kgKG Granulozyten. Das Knochenmark dient zudem als Speicherort: Etwa ¾ der gesamten Granulozyten befinden sich dort als Reserve [4]. Im Falle einer Infektion kann so die Anzahl der neutrophilen Granulozyten im peripheren Blut rasch bis um das 10-Fache ansteigen [5].…”

Section: Fallbeispielunclassified

“…Als physiologischer Normbereich gelten 4000 -10 000/µl Leukozyten (wobei hier je nach Quelle unterschiedliche Angaben gemacht werden) [8]. Allerdings muss dabei bedacht werden, dass der untere Grenzwert in Abhängigkeit von Alter, Geschlecht und ethnischem Hintergrund variieren kann, sodass nicht automatisch jede Leukopenie als pathologisch zu bewerten ist [4,9].…”

Section: Definitionunclassified

“…B. nach zytostatischer Chemotherapie) über 5 Tage andauert. Neben Erregern wie Pilzen, Viren und fakultativ pathologischen Bakterien spielen bei Infektionen im Rahmen einer schweren Neutropenie häufig endogene Keime eine Rolle [4].…”

Section: Merkeunclassified

“…Nach der Entnahme von Urin-und Blutkulturen muss unverzüglich (innerhalb < 2 h) mit einer intravenösen, empirischen antibiotischen Therapie begonnen und der Patient im Regelfall stationär behandelt werden [4,11]. Die Mortalitätsrate bei inadäquat behandelten Patienten mit neutropenem Fieber ist hoch und beträgt z.…”

Section: Merkeunclassified

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Leukopenie – ein diagnostischer Leitfaden für die Praxis

Christen¹,

Brümmendorf²,

Panse³

2017

Dtsch med Wochenschr

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Reasons for leukopenia can be numerous. To get close to the diagnosis it's always useful to check previous blood counts of the patient to get a feeling for the dynamic development of the leukopenia. Furthermore, it's important to check the red blood cell count and platelet count as well; a bi- or a pancytopenia usually implies an insufficient production in the bone marrow. Nevertheless, a manual counted peripheral blood smear is an essential step towards the right diagnosis in leukopenia: Beside cell counts of the single subgroups of leucocytes it also provides information on potential causes such as dysplasia.Leukopenia can be life-threatening for the patient especially if the patient presents with an agranulocytosis and fever: In this case admission is mandatory and the patient has to be treated immediately with broad-spectrum antibiotics to reduce mortality.

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Section: Fallbeispielunclassified

Section: Definitionunclassified

Section: Merkeunclassified

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Leukopenie – ein diagnostischer Leitfaden für die Praxis

Christen¹,

Brümmendorf²,

Panse³

2017

Dtsch med Wochenschr

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“…Disorders of the cellular component of the human immune system may lead to severe disturbances in the homeostasis as body functions are regulated and affected by a variety of cytokines, which are secreted by immune cells such as leukocytes [ 1 , 2 , 3 , 4 ]. A decrease in the concentration of leukocytes below 4000 cells per µL blood is called leukopenia [ 5 ]. Leukocytes are the first responders of innate immunity, and their functional alterability due to internal and external signals is remarkable [ 2 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Morbidity and Mortality of Neutropenic Patients in Visceral Surgery: A Narrative Review

Lederer

Bartsch

Möhler

et al. 2022

Cells

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Leukocytes are essential for the function of the immune system and cell–cell interaction in the human body, but hematological diseases as well as chemotherapeutic treatments due to cancer lead to occasionally or even permanent leukocyte deficiency. Normally, more than 50% of leukocytes are neutrophilic granulocytes, and leukopenia is, therefore, mostly characterized by a decrease in neutrophilic granulocytes. The consequence of neutropenia is increased susceptibility to infection, but also healing disorders are suggestable due to the disturbed cell–cell interaction. While there is no surgical treatment for leucocyte disorders, patients suffering from neutropenia are sometimes in need of surgery for other reasons. Less is known about the morbidity and mortality of this patients, which is why this narrative review critically summarizes the results of recent research in this particular field. The results of this review suggest that neutropenic patients in need of emergency surgery have a higher mortality risk compared to non-neutropenic patients. In contrast, in elective surgery, there was not a clear tendency for a higher mortality risk of neutropenic patients. The role of neutrophilic granulocytes in inflammation and immunity in surgical patients is emphasized by the results, but most of the evaluated studies showed methodological flaws due to small sample sizes or risk of bias. Further research has to evaluate the risk for postoperative complications, particularly of infectious complications such as surgical site infections, in neutropenic patients undergoing elective surgery, and should address the role of neutrophilic function in postoperative morbidity and mortality.

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21/w mit Leukopenie, Neutropenie und fieberhaftem Infektgeschehen

Rückel

2021

Internist

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Practical Approach to the Investigation of Neutropenia

Cited by 9 publications

References 25 publications

Leukopenie – ein diagnostischer Leitfaden für die Praxis

Leukopenie – ein diagnostischer Leitfaden für die Praxis

Morbidity and Mortality of Neutropenic Patients in Visceral Surgery: A Narrative Review

21/w mit Leukopenie, Neutropenie und fieberhaftem Infektgeschehen

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