Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain

Edwards, Scott; Callicoatte, Chelsea N.; Barattini, Angela E.; Cucinello-Ragland, Jessica A.; Melain, Alex; Edwards, Kimberly N.; Gilpin, Nicholas W.; Avegno, Elizabeth M.; Pahng, Amanda R.

doi:10.1016/j.neuropharm.2022.108976

Cited by 10 publications

(3 citation statements)

References 70 publications

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“…Our study shows that acute intraperitoneal posttreatment with PPX reverted formalin‐induced long‐lasting secondary mechanical allodynia and hyperalgesia on Day 6 after formalin injection. In support of our results, acute and subacute (4 days) subcutaneous treatment with PPX decreased complete Freund's adjuvant‐induced mechanical hyperalgesia in a model of inflammatory pain (Edwards et al, 2022). Likewise, acute and subacute (10 days) systemic posttreatment with PPX reverted thermal and mechanical allodynia (Cao et al, 2016; Romero‐Sánchez et al, 2020) and hyperalgesia in rats with Parkinson's disease (Romero‐Sánchez et al, 2020).…”

Section: Discussionsupporting

confidence: 89%

“…PPX prevents the development of inflammation induced by carrageenan, formalin, and tissue plasminogen activator (TPA) (Sadeghi et al, 2017). In addition, studies have demonstrated that PPX inhibits thermal (Cao et al, 2016; Martins et al, 2022) and mechanical (Edwards et al, 2022; Romero‐Sánchez et al, 2020) nociception hypersensitivity in animals with Parkinson's disease, fibromyalgia, and inflammatory pain. This evidence suggests the potential usefulness of PPX as an antinociceptive agent.…”

Section: Introductionmentioning

confidence: 99%

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Pramipexole inhibits formalin‐induce acute and long‐lasting mechanical hypersensitivity via NF‐kB pathway in rats

Santamaria‐Anzures

Pérez‐Ramos

Mendoza‐Pérez

et al. 2023

Drug Development Research

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Pain is one of the most frequent causes for patients to seek medical care. It interferes with daily functioning and affects the quality of life of the patient. There is a clear need to investigate nonopioid or non-nonsteroidal anti-inflammatory drug alternatives for the treatment of pain. In this study, we determined the effect of acute pre-and posttreatment with pramipexole (PPX), a dopamine D2/D3 selective agonist, on formalin 1%-induced acute and long-lasting nociceptive behavior sensitivity in rats.Moreover, we sought to investigate whether the antiallodynic and antihyperalgesic effect induced by PPX was mediated through the nuclear factor-κB (NF-kB) signaling pathway. Moreover, acute systemic pretreatment with PPX (1 and 3 mg/kg, ip) suppressed the formalin-induced nociceptive behavior during both phases of the formalin test and the development of formalin-induced secondary mechanical allodynia and hyperalgesia in both paws. Acute systemic posttreatment with PPX (3 mg/kg, ip) reverted the formalin-induced long-lasting secondary mechanical allodynia and hyperalgesia. Furthermore, PPX inhibits the protein expression of NF-κB-p65 and the levels of tumor necrosis factor-α and interleukin-1β in the spinal cord of animals with secondary mechanical allodynia and hyperalgesia induced by formalin. These data suggest that PPX has a potential role in producing anti-inflammatory activity.Moreover, the antiallodynic and antihyperalgesic effects induced by PPX can be mediated through the NF-kB signaling pathway.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Pramipexole inhibits formalin‐induce acute and long‐lasting mechanical hypersensitivity via NF‐kB pathway in rats

Santamaria‐Anzures

Pérez‐Ramos

Mendoza‐Pérez

et al. 2023

Drug Development Research

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show abstract

“…DA regulates injury perception in various areas of the CNS, including the basal ganglia, thalamus, insular cortex, anterior cingulate cortex and periaqueductal gray (PAG). 59,60 The PAG is a brain region involved in the regulation of injury perception, and MOR is densely expressed in the PAG. [61][62][63] Given the central role of opioid receptors in mediating pain and their dense expression in the PAG, researchers investigated whether there is a link between them and dopamine in the regulation of pain and found that the ventral PAG/dorsal raphe dopamine neurons may play a key role in opioid anti-harm perception through the activation of downstream structures by dopamine and glutamate release.…”

Section: Dopaminementioning

confidence: 99%

The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain

Zhu¹,

Huang²

2023

NSS

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Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals and humans, for example by increasing sensitivity to pain. However, the mechanism by which sleep affects neuropathic pain remains unclear. In this review, we discuss the available evidence from the epidemiologic, clinical, and human, as well as laboratory studies. In previous studies, we have found that sleep deprivation affects various injurious systems, including opioids, dopaminergic, immune, orexins, hypothalamicpituitary-adrenal axis, and adenosine. At the same time, these systems play a crucial role in neuropathic pain regulation. In the complex interactions between these neurobiological systems, there may be potential regulatory pathways through which sleep deprivation amplifies neuropathic pain. Because of the impact sleep problems and neuropathic pain can have on the patients' quality of life, studying the link between sleep and neuropathic pain is important for neuropathic pain prevention and public health.

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Interactions of pain and opioids on conditioned place preference in rodents

Barattini,

Pahng

2024

Psychopharmacology

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Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain

Cited by 10 publications

References 70 publications

Pramipexole inhibits formalin‐induce acute and long‐lasting mechanical hypersensitivity via NF‐kB pathway in rats

Pramipexole inhibits formalin‐induce acute and long‐lasting mechanical hypersensitivity via NF‐kB pathway in rats

The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain

Interactions of pain and opioids on conditioned place preference in rodents

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