Pre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats

Chatterjee, Pratik Kumar; Anantharaya, Vinodini Nithyananda Madom; Shiva, Rashmi Kaup; Kumar, Nayanatara Arun; Shetty, Sneha B; Budihal, Suman V.; Bhat, Mangalore Ramesh; Kunal, .

doi:10.5530/pj.2017.6.132

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Sexual hormone directly stimulates spermatogenesis therefore, a significant increase in these hormones lead to increased sperm cell count and motility as observed in this study. Similar findings were reported by (Gauthaman and Adaikan, 2008;Prabsattroo et al;Harrison et al, 2016Nithya and Elango, 2016 ;Chatterjee et al, 2017 andDafaalla et al ., 2017) Moringa oleifera leaves contain antioxidants, Saponins have been reported to boost testosterone levels.…”

Section: Discussionsupporting

confidence: 88%

Comparative Study On Some Medicinal Plants Against – Cisplatin Induced Infertility In Male Rats

2018

Egyptian Journal of Nutrition

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This study was conducted to investigate the effect of some medicinal plants against cisplatin induced infertility in experimental male rats. Thirty mature albino rats weighing 180-220g. Rats used in this study divided into 6 equal groups, one was kept as a control-ve group, while the other 5 groups were injected intraperitoneally(IP) with a single dose of cisplatin (CP) (7ml / kg B.Wt.). After induction, one group was kept as (+ve) control group, while others given administration of medicinal plants [ethanolic extract of Psidium guajava leaves (EEPGL) and ethanolic extract of Moringa oleifera leaves (EEMOL) (100 and 200 mg/kg)] orally for six weeks. Biological evaluation including feed intake (FI), body weight gain % (BWG %) and feed efficiency ratio (FER) was carried. Sperm count, Sperm motility and sperm head abnormality were calculated. Serum (Testosterone, luteinizing (LH) and follicle stimulating (FSH) hormones were measured. Serum antioxidant enzymes (Super Oxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAT), level of Malondialdehyde (MDA) and nitric oxide (No) were estimated. Also histopathological changes for testis, were examined. The obtained results concluded that using EEPGL and EEMOL improved FI, BWG % and FER, sperm count, Sperm motility, sperm Hanan S. E. Eldamaty and Suzan S. Ibraheim 206 abnormality, serum hormones and antioxidant enzymes. The best results found by using high doses (200mg / kg) of EEPGL and EEMOL. According to the results, EEPGL and EEMOL could be used for improved sexual functions and protection from infertility,in male rats

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Section: Discussionsupporting

confidence: 88%

Comparative Study On Some Medicinal Plants Against – Cisplatin Induced Infertility In Male Rats

2018

Egyptian Journal of Nutrition

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“…Similarly, when rats were given a single oral supplementation of 10 mg/kg body weight of CdCl 2 , a significant decrease in the level of serum testosterone and increased lipid peroxidation (MDA) were noted. Increased level of MDA suggests that CdCl 2 -induced oxidative stress causes testicular damage by increasing ROS production [ 194 ]. When 2.5 mg/kg body weight CdCl 2 was orally supplemented to two groups of male rats for 14 and 42 days, respectively, it caused a duration-dependent decrease in testosterone levels, FSH, and LH along with decreased semen quality parameters and gonadosomatic index [ 195 ].…”

Section: Environmental Factorsmentioning

confidence: 99%

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

et al. 2021

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Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary–gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hypogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCOPUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive pathways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED.

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“…3 Its major constituents include cinnamaldehyde and trans-cinnam-aldehyde. They are present in the essential oils thus adding fragrance and biological activities to them 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Its essential oil holds antimicrobial properties thus used as a preservative in food industry. 4 It also plays vital role in treatment of type-II diabetes, hyperlipidemias as revealed by studies. 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Cinnamon Bark Oil on Leydig Cell Count and Morphology along with Serum Testosterone Levels in Rats after Cadmium Induced Testicular Toxicity

Muhammad¹,

Muhammad²,

Aslam³

et al. 2021

PJMHS

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Cadmium is a toxic heavy metal that causes number of health issues. Purpose: To demonstrate the effect of cinnamon bark oil on Leydig cell count and morphology with measurement of serum testosterone levels. Study Design: Experimental study. Methodology: Healthy male wistar rats (n=30) were taken and divided into 3 groups with n= 10. Group A functioned as control. Cadmium chloride was administered to the rats to induce testicular toxicity in group B. Group C was the treatment group. Animals were euthanized on day 15. Leydig cell count and morphology was done after haematoxylin and eosin staining of the testicular tissue sections. Serum testosterone level was done by ELISA. Statistical analysis: Data analyzed by SPSS 22.0v. Results: Cadmium chloride was observed to significantly reduce leydig cell counts and serum testosterone levels in group B. No significant effect was observed on the morphology of the leydig cells. Cinnamon bark oil significantly improved the leydig cell count. Serum testosterone levels were observed to increase after the cinnamon bark oil administration. Conclusion: This study clearly showed that cinnamon bark oil has protective effect on the cadmium induced testicular toxicity. Key Words: Enzyme Linked Immuno-sorbent Assay, High Density Lipoprotein, Cinnamon Bark Oil and Optical Density.

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Pre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats

Cited by 6 publications

References 19 publications

Comparative Study On Some Medicinal Plants Against – Cisplatin Induced Infertility In Male Rats

Comparative Study On Some Medicinal Plants Against – Cisplatin Induced Infertility In Male Rats

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

Effect of Cinnamon Bark Oil on Leydig Cell Count and Morphology along with Serum Testosterone Levels in Rats after Cadmium Induced Testicular Toxicity

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