Pre- and postnatal exposure to low-dose diesel exhaust impairs murine spermatogenesis

Kubo-Irie, Miyoko; Oshio, Shigeru; Niwata, Yuichiro; Ishihara, Akimitsu; Sugawara, Isamu; Takeda, Ken

doi:10.3109/08958378.2011.610834

Cited by 10 publications

(11 citation statements)

References 31 publications

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“… Enter fetus (Semmler-Behnke et al, 2007 ). Collagen in offspring (Takahashi and Matsuoka, 1981 ), interrupt male reproductive system and decrease DSP (Kubo-Irie et al, 2011 ). Toxic effects in embryo (Wang et al, 2007 ), irregular expression of genes in offspring livers (Takahashi et al, 2010 ), inhibition in female offspring (Fujimoto et al, 2005 ).…”

Section: Transplacental Transfermentioning

confidence: 99%

Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review

et al. 2017

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In the last two decades, nanotechnologies demonstrated various applications in different fields, including detection, sensing, catalysis, electronics, and biomedical sciences. However, public concerns regarding the well-being of human may hinder the wide utilization of this promising innovation. Although, humans are exposed to airborne nanosized particles from an early age, exposure to such particles has risen dramatically within the last century due to anthropogenic sources of nanoparticles. The wide application of nanomaterials in industry, consumer products, and medicine has raised concerns regarding the potential toxicity of nanoparticles in humans. In this review, the effects of nanomaterials on the reproductive system in animal models are discussed. Females are particularly more vulnerable to nanoparticle toxicity, and toxicity in this population may affect reproductivity and fetal development. Moreover, various types of nanoparticles have negative impacts on male germ cells, fetal development, and the female reproductive system. These impacts are associated with nanoparticle modification, composition, concentration, route of administration, and the species of the animal. Therefore, understanding the impacts of nanoparticles on animal growth and reproduction is essential. Many studies have examined the effects of nanoparticles on primary and secondary target organs, with a concentration on the in vivo and in vitro effects of nanoparticles on the male and female reproductive systems at the clinical, cellular, and molecular levels. This review provides important information regarding organism safety and the potential hazards of nanoparticle use and supports the application of nanotechnologies by minimizing the adverse effects of nanoparticles in vulnerable populations.

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Section: Transplacental Transfermentioning

confidence: 99%

Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review

et al. 2017

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“…DE has been shown to disrupt the reproductive development of offspring [55,56]. Pre- and postnatal exposure of ICR mice to DE at a dose of 0.17 mg/m 3 caused a reduced daily sperm production (DSP) and deformed the sertoli and spermatozoa cells in the offspring [57]. …”

Section: Effects Of Nanotoxicity On Female Reproductivity and Devementioning

confidence: 99%

Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models

Sun

Zhang

Wang

et al. 2013

IJMS

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The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.

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“…In males, detrimental effects including reduction of daily sperm production, endocrine disruption affecting steroids and gonadotropins, decrease of the number of Sertoli cells presenting damaged mitochondria were reported after diesel exhaust (DE) exposure during the pre-or postnatal period. [17][18][19][20] In females, prenatal exposure to air pollution has been shown to induce a dramatic decrease in the size of the gonads due to alterations in germ cell development, gametogenesis and folliculogenesis that negatively affects the ovarian follicular reserve in offspring. [21][22][23][24][25][26][27] All these studies were done in rodents, mainly by exposure of the entire animals during gestation, and in some cases during lactation as well.…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23][24][25][26][27] All these studies were done in rodents, mainly by exposure of the entire animals during gestation, and in some cases during lactation as well. 19,24,25 Questions remain which are difficult to answer: was the mother contaminated by ingestion (leaking) of pollutants or by inhalation? By which mechanism (acting on germ cell mitosis, or meiosis; or acting on somatic cells differentiation) does pollution affect the gonad?…”

Section: Introductionmentioning

confidence: 99%

Impact of a gestational exposure to diesel exhaust on offspring gonadal development: experimental study in the rabbit

Torres-Rovira

Monniaux

Faure

et al. 2018

J Dev Orig Health Dis

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The aim of the present work was to address experimentally the possible impact of exposure to air pollution during gestation on the differentiation and function of the gonads of the offspring using a rabbit model. Rabbits were exposed daily to diluted diesel exhaust gas or filtered air from the 3rd until the 27th day of gestation, during which time germ cells migrate in genital ridges and divide, and fetal sex is determined. Offspring gonads were collected shortly before birth (28th day of gestation) or after puberty (7.5 months after birth). The structure of the gonads was analyzed by histological and immunohistological methods. Serum concentrations of testosterone and anti-Müllerian hormone were determined using ELISA. The morphology and the endocrine function of the gonads collected just at the arrest of the exposure were similar in polluted and control animals in both sexes. No differences were observed as well in gonads collected after puberty. Sperm was collected at the head of the epididymis in adults. Sperm motility and DNA fragmentation were measured. Among all parameters analyzed, only the sperm DNA fragmentation rate was increased three-fold in exposed males. Mechanisms responsible for these modifications and their physiological consequences are to be further clarified.

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Pre- and postnatal exposure to low-dose diesel exhaust impairs murine spermatogenesis

Cited by 10 publications

References 31 publications

Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review

Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review

Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models

Impact of a gestational exposure to diesel exhaust on offspring gonadal development: experimental study in the rabbit

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