Pre- and Postnatal Fine Particulate Matter Exposure and Childhood Cognitive and Adaptive Function

McGuinn, Laura A.; Wiggins, Lisa D.; Volk, Heather E.; Di, Qian; Moody, Eric J.; Kasten, Eric P.; Schwartz, Joel; Wright, Robert O.; Schieve, Laura A.; Windham, Gayle C.; Daniels, Julie L.

doi:10.3390/ijerph19073748

Cited by 10 publications

(14 citation statements)

References 36 publications

(43 reference statements)

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“…17 Prenatal PM2.5 exposures was associated with deficits in communication 17,18 and was associated with lower functioning on the expressive language subscale among developmental delay cases. 19 Lertxundi et al found a significant negative association between prenatal PM2.5 exposures with verbal domain among males. 20 Motor skills symptoms Seven articles discussed on motor skills symptoms.…”

Section: Learning/cognitivementioning

confidence: 97%

“…17,18 • Lower functioning on the expressive language subscale among developmental delay cases. 19 • Negative association between prenatal PM2.5 exposures with verbal domain among males. 20…”

Section: Symptomsmentioning

confidence: 99%

“…• Lower MSEL scores. 19 • Predicted lower cognitive score. 16 • Increase risk of suspected development delay.…”

Section: Learning/cognitivementioning

confidence: 99%

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Prenatal PM2.5 Exposure and Its Association with Neurodevelopmental Impairment in Children: A Narrative Review

Hamis,

Shaharuddin,

A Fauzi

et al. 2023

IJPHR

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Air pollutants including PM2.5 are an increasing threat to public health. Studies have reported the adverse effect of PM2.5 exposure during pregnancy on neurodevelopment in children. We performed a narrative review using the PubMed, Web of Science and Scopus databases using keywords such as prenatal, particulate matter, neurodevelopment, and children. This review aims to identify symptoms of impaired neurodevelopment in children associated with prenatal PM2.5 exposure, the association between the timing of prenatal exposure PM2.5 and symptoms of impaired neurodevelopment in children as well as other factors that may influence the association of prenatal PM2.5 exposure and symptoms of impaired neurodevelopment in children. 25 papers were included in this review. There are ranges of symptoms of neurodevelopmental impairment associated with prenatal exposure of PM2.5, including language, speech, and communication symptoms; motor skills; behaviour and social skills; memory as well as learning/cognitive symptoms. Neurodevelopmental impairments were associated with exposure to PM2.5 across all three trimesters with impairment in communication and behavioural domains predominate in those exposed during the first trimester. Generally, male was more susceptible to having neurodevelopmental impairment symptoms compared to females. More information regarding the effect of prenatal PM2.5 exposure towards neurodevelopmental domains of the children will support public health policies that reduce air pollution and improve children’s health.

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Section: Learning/cognitivementioning

confidence: 97%

Section: Symptomsmentioning

confidence: 99%

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Prenatal PM2.5 Exposure and Its Association with Neurodevelopmental Impairment in Children: A Narrative Review

Hamis,

Shaharuddin,

A Fauzi

et al. 2023

IJPHR

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“…Susceptibility to ASD is determined by an interplay of genetic and environmental influences. Researchers discovered that contact with PM 2.5 during the prenatal and postnatal periods increases susceptibility of a child toward ASD [ 40 , 69 ].…”

Section: Neurodevelopmental Toxicity Caused By Pm 25mentioning

confidence: 99%

Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

Yan,

Ma,

Liu

et al. 2024

Toxics

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Particulate matter of size ≤ 2.5 μm (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by the rapid research progress in this field, the existing research on developmental toxicity is still constrained by limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes the currently available epidemiological and laboratory evidence and comprehensively characterizes the adverse effects of PM2.5 on developing individuals in different regions and various pollution sources. In addition, this review explores the effect of PM2.5 exposure to individuals of different ethnicities, genders, and socioeconomic levels on adverse birth outcomes and cardiopulmonary and neurological development. Furthermore, the molecular mechanisms involved in the adverse health effects of PM2.5 primarily encompass transcriptional and translational regulation, oxidative stress, inflammatory response, and epigenetic modulation. The primary findings and novel perspectives regarding the association between public health and PM2.5 were examined, highlighting the need for future studies to explore its sources, composition, and sex-specific effects. Additionally, further research is required to delve deeper into the more intricate underlying mechanisms to effectively prevent or mitigate the harmful effects of air pollution on human health.

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“…The first studies to utilize satellite-based observations for public health applications looked at Aerosol Optical Depth (AOD) data to examine the relation between environmental pollution and autism spectrum disorder (ASD) [20] and impaired adaptive and cognitive functioning [21] following early life exposure to PM 2.5 .…”

Section: Satellite Data Sources For Public Health Researchmentioning

confidence: 99%

“Urban-Satellite” estimates in the ABCD Study: Linking Neuroimaging and Mental Health to Satellite Imagery Measurements of Macro Environmental Factors

Goldblatt,

Holz,

Tate

et al. 2023

Preprint

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While numerous studies over the last decade have highlighted the important influence of environmental factors on mental health, globally applicable data on physical surroundings are still limited. Access to such data and the possibility to link them to epidemiological studies is critical to unlocking the relationship of environment, brain and behaviour and promoting positive future mental health outcomes. The Adolescent Brain Cognitive Development (ABCD) Study is the largest ongoing longitudinal and observational study exploring brain development and child health among children from 21 sites across the United States. Here we describe the linking of the ABCD study data with satellite-based “Urban-Satellite” (UrbanSat) variables consisting of 11 satellite-data derived environmental indicators associated with each subject’s residential address at their baseline visit, including land cover and land use, nighttime lights, and population characteristics. We present these UrbanSat variables and provide a review of the current literature that links environmental indicators with mental health, as well as key aspects that must be considered when using satellite data for mental health research. We also highlight and discuss significant links of the satellite data variables to the default mode network clustering coefficient and cognition. This comprehensive dataset provides the foundation for large-scale environmental epidemiology research.

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Pre- and Postnatal Fine Particulate Matter Exposure and Childhood Cognitive and Adaptive Function

Cited by 10 publications

References 36 publications

Prenatal PM2.5 Exposure and Its Association with Neurodevelopmental Impairment in Children: A Narrative Review

Prenatal PM2.5 Exposure and Its Association with Neurodevelopmental Impairment in Children: A Narrative Review

Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives

“Urban-Satellite” estimates in the ABCD Study: Linking Neuroimaging and Mental Health to Satellite Imagery Measurements of Macro Environmental Factors

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