Pre-Concentration Approaches Combined with Capillary Electrophoresis in Bioanalysis of Chiral Cardiovascular Drugs

Hamidi, Samin; Jouyban, Abolghasem

doi:10.15171/ps.2015.42

Cited by 27 publications

(10 citation statements)

References 86 publications

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“…Various methods were reported for the determination of tramadol including chromatography [11][12][13][14][15][16][17][18], electrophoresis [19,20], and electrochemical methods [21]. Biological matrices containing a large amount of proteins, salts, and lipids are required to be cleaned-up prior to being coupled with the majority of analytical devices due to the clogging risk of the column [22][23][24]. LLE and SPE are commonly employed as sample preparation methods in the extraction of target analyte from aqueous or biological samples [25,26].…”

Section: Introductionmentioning

confidence: 99%

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Taghvimi

Hamidi

Javadzadeh

2018

J of Separation Science

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Ionic liquid carbon‐coated magnetic nanoparticles were successfully applied as an adsorbent in a mixed hemimicelle magnetic dispersive solid‐phase extraction method for the determination of tramadol from urine samples coupled with high‐performance liquid chromatography with UV‐vis detection. The significant parameters affect the extraction efficiency including type and amount of adsorbent, sample volume, pH, ionic strength, type and amount of elution solvent, time of extraction and desorption, time of ionic liquid loading on the adsorbent and stirring rate were studied and optimized. The proposed method provided a fast, straightforward, environmentally friendly and adsorbent recyclable approach for tramadol analysis. The linear range for the tramadol determination was from 100 to 1500 ng/mL. Precisions and accuracies were within 6%. The applicability of the proposed method in clinical trial was tried successfully on determination of tramadol in addicted subjects under tramadol therapy. The mean percent recovery of the patient samples was 94%. The results proved that the proposed method could be applied in clinical and forensic laboratories for determination of tramadol from biological urine samples.

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Section: Introductionmentioning

confidence: 99%

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Taghvimi

Hamidi

Javadzadeh

2018

J of Separation Science

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“…8 CE has developed over the years into a highly efficient separation technique and is currently applied in several different areas of drug analysis such as chiral separations, with advantages related with the small expenditure of reagents, analytes and chiral selectors, rapid method development, fast migration times and high diversity in choosing and changing chiral selectors. 9,10 Basically, in CE usually a direct method of enantioseparation is applied, by merely dissolving the chiral selector into the background electrolyte (BGE) solution; method which has the advantage of promoting highly efficient separations at a reasonable cost. 11 Tramadol is a basic analyte, a tertiary amine, with a pKa value of around 9.5, consequently can be ionized in an acidic environment and hence its determination by CE becomes feasible.…”

Section: Introductionmentioning

confidence: 99%

Capillary Electrophoresis Methods for the Determination of Tramadol: A Review

et al. 2019

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Tramadol is a widely used opioid analgesic frequently prescribed for treatment of moderate to severe, acute and chronic pain. It has a complex mechanism of action, acting both as a central opiate agonist and as a norepinephrine and serotonin reuptake inhibitor. It is a chiral substance, having two chiral centers in its structure and it is used in therapy as a racemic mixture of two of its enantiomers, (S,S)-tramadol and (R,R)-tramadol. In the last 25 years, several analytical procedures have been published in the literature for the achiral and chiral determination of tramadol from pharmaceutical formulations and biological matrices. Among these methods, capillary electrophoresis techniques have proved to be an efficient, reliable and cost-effective solution. The purpose of the present review is to provide a systematic survey to present and discuss the electrodriven methods available in the literature for the achiral and chiral analysis of tramadol.

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“…Dopamine, which is mostly known as a neurotransmitter, is a nontoxic chemical in the catecholamine family, which could be easily polymerized in weak alkaline condition . CE is a reliable separation tool for a wide range of analytes in diverse research areas, including clinical, forensic, and pharmaceutical applications, and chiral separation . The combination of general electrophoretic preconcentration approaches is a strategy that could improve the ratio of signal to noise without any modifications to the apparatus .…”

Section: Introductionmentioning

confidence: 99%

Dispersive micro‐solid‐phase extraction using carbon‐based adsorbents for the sensitive determination of verapamil in plasma samples coupled with capillary electrophoresis

Jouyban

Hamidi

2017

J of Separation Science

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A dispersive micro-solid-phase extraction procedure coupled with capillary electrophoresis ultraviolet detection was developed for determination of verapamil in plasma samples. Graphene oxide/polydopamin was synthesized by a one-step polymerization method, and graphene oxide/Fe O (magnetic graphene oxide) nanocomposite was prepared by coprecipitation method. Moreover, they were fully characterized. The use of hazardous and water-immiscible solvents was scaled down, and only 500 μL of acetone was required as the desorption solvent. The detector response concentration plots were linear in the range of 5-500 ng/mL, and the proposed method was validated according to guidelines. The precision and accuracy were less than 15%. Dispersive micro-solid-phase extraction method provides a rapid, environmentally friendly, and sensitive analysis for the verapamil in patient plasma samples, which is adequate for therapeutic drug monitoring and pharmacokinetic studies.

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Pre-Concentration Approaches Combined with Capillary Electrophoresis in Bioanalysis of Chiral Cardiovascular Drugs

Cited by 27 publications

References 86 publications

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Capillary Electrophoresis Methods for the Determination of Tramadol: A Review

Dispersive micro‐solid‐phase extraction using carbon‐based adsorbents for the sensitive determination of verapamil in plasma samples coupled with capillary electrophoresis

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