Pre-training to find a hidden platform in the Morris water maze can compensate for a deficit to find a cued platform in a rat model of Parkinson’s disease

Cunha, Cláudio Da; Wietzikoski, Samantha; Wietzikoski, Evellyn Claudia; Silva, Marcio H C; Chandler, Jeff; Ferro, Marcelo Machado; Andreatini, Roberto; Canteras, Newton S.

doi:10.1016/j.nlm.2006.12.004

Cited by 20 publications

(11 citation statements)

References 52 publications

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“…We did not observe such a deficit in this study, and this may be the result of testing differences. Here, the cued task followed spatial acquisition and conducting spatial learning prior to procedural learning has been shown to eliminate deficits in cued learning following intranigral MPTP injections (Da Cunha et al, 2007); therefore, test order may account for this apparent inconsistency. Cued vs. hidden platform MWM testing was not counterbalanced here in order to keep the methods between this study and our previous study consistent.…”

Section: Discussionmentioning

confidence: 99%

Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats

Braun

Graham

Schaefer

et al. 2012

Neurobiology of Learning and Memory

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Successful navigation requires interactions among multiple but overlapping neural pathways mediating distinct capabilities, including egocentric (self-oriented, route-based) and allocentric (spatial, map-based) learning. Route-based navigation has been shown to be impaired following acute exposure to the dopaminergic (DA) drugs (+)-methamphetamine and (+)-amphetamine, but not the serotoninergic (5-HT) drugs (±)-3,4-methylenedioxymethamphetamine or (±)-fenfluramine. The dopaminergic-rich neostriatum is involved in both allocentric and egocentric navigation. This experiment tested whether dorsal striatal DA loss using bilateral 6-hydroxydopamine (6-OHDA) injections impaired one or both types of navigation. Two weeks following 6-OHDA injections, rats began testing in the Cincinnati water maze (CWM) followed by the Morris water maze (MWM) for route-based and spatial navigation, respectively. 6-OHDA treatment significantly increased latency and errors in the CWM and path length, latency, and cumulative distance in the MWM with no difference on cued MWM trials. Neostriatal DA levels were reduced by 80% at 2 and 7 weeks post-treatment. In addition, 6-OHDA increased DA turnover and decreased norepinephrine (NE) levels. 6-OHDA injections did not alter monoamine levels in the prefrontal cortex. The data support that neostriatal DA modulates both types of navigation.

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Section: Discussionmentioning

confidence: 99%

Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats

Braun

Graham

Schaefer

et al. 2012

Neurobiology of Learning and Memory

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“…We employed several established tasks to evaluate cognitive function including the: (1) perirhinal cortex (PRh)-dependent novel object recognition (NOR) task (27, 28); (2) hippocampal-dependent standard Morris water maze (MWM) task (29, 30); (3) hippocampal-dependent delayed match-to-place (DMTP) version of the MWM (31); and (4) cue strategy preference version of the MWM (32, 33) that distinguishes hippocampal from striatal task performance.…”

Section: Introductionmentioning

confidence: 99%

The Peroxisomal Proliferator-Activated Receptor (PPAR) α Agonist, Fenofibrate, Prevents Fractionated Whole-Brain Irradiation-Induced Cognitive Impairment

et al. 2014

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We hypothesized that dietary administration of the peroxisomal proliferator-activated receptor α agonist, fenofibrate, to young adult male rats would prevent the fractionated whole-brain irradiation (fWBI)-induced reduction in cognitive function and neurogenesis and prevent the fWBI-induced increase in the total number of activated microglia. Eighty 12–14-week-old young adult male Fischer 344 × Brown Norway rats received either: (1) sham irradiation, (2) 40 Gy of fWBI delivered as two 5 Gy fractions/week for 4 weeks, (3) sham irradiation + dietary fenofibrate (0.2% w/w) starting 7 days prior to irradiation, or (4) fWBI + fenofibrate. Cognitive function was measured 26–29 weeks after irradiation using: (1) the perirhinal cortex (PRh)-dependent novel object recognition task; (2) the hippocampal-dependent standard Morris water maze (MWM) task; (3) the hippocampal-dependent delayed match-to-place version of the MWM task; and (4) a cue strategy preference version of the MWM to distinguish hippocampal from striatal task performance. Neurogenesis was assessed 29 weeks after fWBI in the granular cell layer and subgranular zone of the dentate gyrus using a doublecortin antibody. Microglial activation was assessed using an ED1 antibody in the dentate gyrus and hilus of the hippocampus. A significant impairment in perirhinal cortex-dependent cognitive function was measured after fWBI. In contrast, fWBI failed to alter hippocampal-dependent cognitive function, despite a significant reduction in hippocampal neurogenesis. Continuous administration of fenofibrate prevented the fWBI-induced reduction in perirhinal cortex-dependent cognitive function, but did not prevent the radiation-induced reduction in neurogenesis or the radiation-induced increase in activated microglia. These data suggest that fenofibrate may be a promising therapeutic for the prevention of some modalities of radiation-induced cognitive impairment in brain cancer patients.

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“…NSPT teaches necessary behavioral components of the task while precluding spatial map formation. Furthermore, NSPT teaches rats to suppress thigmotaxis and to utilize the platform as an escape (Hoh & Cain, 1997; Da Cunha et al, 2007). NSPT also likely reduces the emotional stress that animals experience in reaction to a novel task, particularly when completing initial acquisition trials.…”

Section: Discussionmentioning

confidence: 99%

Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI

Wagner

Brayer

Hurwitz

et al. 2013

Neurobiology of Learning and Memory

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Explicit and implicit learning and memory networks exist where each network can facilitate or inhibit memory. Clinical evidence suggests that implicit networks are relatively preserved after traumatic brain injury (TBI). Non-spatial pre-training (NSPT) in the Morris water maze (MWM) provides the necessary behavioral components to complete the task, while limiting the formation of spatial maps. Our study utilized NSPT in the MWM to assess implicit and explicit learning and memory system deficits in the controlled cortical impact (CCI) model of TBI. 76 adult male Sprague-Dawley rats were divided: CCI vs. sham surgery, NSPT vs. No-NSPT, and cued vs. non-cued groups. NSPT occurred for 4d prior to surgery (dynamic hidden platform location, extra-maze cues covered, static pool entry point). Acquisition (d14–18), Probe/Visible Platform (d19), and Reversal (d20–21) trials were conducted with or without extra-maze cues. Novel time allocation and search strategy selection metrics were utilized. Results indicated implicit and explicit learning/memory networks are distinguishable in the MWM. In the cued condition, NSPT reduced thigmotaxis, improved place learning, and largely eliminated the apparent injury-induced deficits typically observed between untrained CCI and sham rats. However, among NSPT groups, incorporation of cues into search strategy selection for CCI rats was relatively impaired compared to shams. Non-cued condition performance showed sham/NSPT and CCI/NSPT rats perform similarly, suggesting implicit memory networks are largely intact 2 weeks after CCI. Place learning differences between CCI/NSPT and sham/NSPT rats more accurately reflect spatial deficits in our CCI model compared to untrained controls. These data suggest NSPT as a clinically relevant construct for evaluating potential neurorestorative and neuroprotective therapies. These findings also support development of non-spatial cognitive training paradigms for evaluating rehabilitation relevant combination therapies.

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Pre-training to find a hidden platform in the Morris water maze can compensate for a deficit to find a cued platform in a rat model of Parkinson’s disease

Cited by 20 publications

References 52 publications

Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats

Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats

The Peroxisomal Proliferator-Activated Receptor (PPAR) α Agonist, Fenofibrate, Prevents Fractionated Whole-Brain Irradiation-Induced Cognitive Impairment

Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI

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