2020
DOI: 10.1371/journal.pone.0219722
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Pre-warming before general anesthesia with isoflurane delays the onset of hypothermia in rats

Abstract: General anesthesia causes hypothermia by impairing normal thermoregulatory mechanisms. When using inhalational anesthetic agents, Redistribution of warm blood from the core to the periphery is the primary mechanism in the development of hypothermia and begins following induction of anesthesia. Raising skin temperature before anesthesia reduces the temperature gradient between core and periphery, decreasing the transfer of heat. This prospective, crossover study (n = 17 adult male and female SD rats) compared t… Show more

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Cited by 22 publications
(19 citation statements)
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“…Isoflurane depresses respiration without altering cardiac function (22), and increases cerebral blood flow (23). In addition, both ketamine and isoflurane induce hypothermia in small animals (24,25). Changes in physiological parameters, such as cerebral blood flow and cardiac output, can in turn affect the biodistribution of PET tracers (8).…”
Section: Effects Of Anesthesia In Brain Petmentioning
confidence: 99%
“…Isoflurane depresses respiration without altering cardiac function (22), and increases cerebral blood flow (23). In addition, both ketamine and isoflurane induce hypothermia in small animals (24,25). Changes in physiological parameters, such as cerebral blood flow and cardiac output, can in turn affect the biodistribution of PET tracers (8).…”
Section: Effects Of Anesthesia In Brain Petmentioning
confidence: 99%
“…Rats were instrumented with a telemetry capsule (Anipill temperature sensor; Aniview system, Bodycap, Hérouville-Saint-Clair, France) implanted in the peritoneal cavity to monitor core temperature as part of a related study. 28 Capsule implantation was performed 10 wk before the experiments began.…”
Section: Animalsmentioning
confidence: 99%
“…The chamber used for prewarming and anesthetic induction (25.7 [l] x 11 [w] x 10.7 [h] cm; Small box, Harvard apparatus, Holliston, MA) was preheated to a temperature of 32.6 ± 1.1 °C (measured with a calibrated infrared thermometer) using a purpose-built heating unit (Vetronic Services, England). 28 To achieve prewarming, a single rat was placed in the chamber, where it remained its core temperature increased to 1% above the value recorded before entry into the chamber. Once the prewarming target was attained, isoflurane was started (5% isoflurane on the vaporizer dial carried in 1L/ min oxygen) and general anesthesia was induced.…”
Section: Animalsmentioning
confidence: 99%
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